Literature DB >> 24186323

Structure-lipophilicity relationships of peptides and peptidomimetics.

N El Tayar1, H Karajiannis, H van de Waterbeemd.   

Abstract

Understanding the physicochemical and structural properties of peptides are important prerequisites for the rational design of bioactive peptides and peptidomimetics. The present contribution reviews methods used for the assessment and prediction of lipophilicity (or hydrophobicity) and their correlation with structural elements of peptides and closely related peptidomimetics.

Year:  1995        PMID： 24186323     DOI： 10.1007/BF00806487

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  28 in total

1.  Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors.

Authors:  S Trumpp-Kallmeyer; J Hoflack; A Bruinvels; M Hibert
Journal:  J Med Chem       Date:  1992-09-18       Impact factor: 7.446

2.  Design, synthesis and conformational analysis of gamma-turn peptide mimetics of bradykinin.

Authors:  M Sato; J Y Lee; H Nakanishi; M E Johnson; R A Chrusciel; M Kahn
Journal:  Biochem Biophys Res Commun       Date:  1992-09-16       Impact factor: 3.575

3.  Quantitative analyses of hydrophobicity of di- to pentapeptides having un-ionizable side chains with substituent and structural parameters.

Authors:  M Akamatsu; T Fujita
Journal:  J Pharm Sci       Date:  1992-02       Impact factor: 3.534

4.  Determination of the lipophilicity of some peptides. Effect of surface pH of silica.

Authors:  T Cserháti; M Szögyi
Journal:  J Chromatogr       Date:  1990-11-09

Review 5.  Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

Authors:  V J Hruby; F al-Obeidi; W Kazmierski
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

6.  The design and synthesis of mimetics of peptide beta-turns.

Authors:  M Kahn; S Wilke; B Chen; K Fujita; Y H Lee; M E Johnson
Journal:  J Mol Recognit       Date:  1988-04       Impact factor: 2.137

7.  Observation of a conformational effect in peptide molecule by reversed-phase high-performance liquid chromatography.

Authors:  M Lebl
Journal:  J Chromatogr       Date:  1993-08-06

8.  Synthesis, conformational properties, and antibody recognition of peptides containing beta-turn mimetics based on alpha-alkylproline derivatives.

Authors:  M G Hinds; J H Welsh; D M Brennand; J Fisher; M J Glennie; N G Richards; D L Turner; J A Robinson
Journal:  J Med Chem       Date:  1991-06       Impact factor: 7.446

9.  Structural engineering of the HIV-1 protease molecule with a beta-turn mimic of fixed geometry.

Authors:  M Baca; P F Alewood; S B Kent
Journal:  Protein Sci       Date:  1993-07       Impact factor: 6.725

10.  4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.

Authors:  T K Sawyer; P J Sanfilippo; V J Hruby; M H Engel; C B Heward; J B Burnett; M E Hadley
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205
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  1 in total

1.  Versatile methodology for the synthesis and α-functionalization of (2R,3aS,7aS)-octahydroindole-2-carboxylic acid.

Authors:  Francisco J Sayago; M Isabel Calaza; Ana I Jiménez; Carlos Cativiela
Journal:  Tetrahedron       Date:  2008-01-01       Impact factor: 2.457
  1 in total

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