| Literature DB >> 3110081 |
P Vander Elst, E van den Berg, H Pepermans, L vander Auwera, R Zeeuws, D Tourwe, G van Binst.
Abstract
The active sequence Phe7-D-Trp8-Lys9-Thr10 of somatostatin has been cyclized through o-(aminomethyl)phenylacetic acid, a spacer molecule, designed to mimic a Gly-Gly dipeptide containing a cis-constrained peptide bond. The resulting analogue shows no GH-inhibition. A 2D n.m.r. study reveals conformations different from the proposed bio-active one and still sensitive to the medium (solvent).Entities:
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Year: 1987 PMID： 3110081 DOI： 10.1111/j.1399-3011.1987.tb02259.x
Source DB: PubMed Journal: Int J Pept Protein Res ISSN： 0367-8377