Literature DB >> 21587251

Getting pharmaceutical R&D back on target.

Mark E Bunnage1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21587251     DOI： 10.1038/nchembio.581

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


× No keyword cloud information.
  21 in total

Review 1.  Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

Authors:  Peter Buchwald
Journal:  IUBMB Life       Date:  2010-10       Impact factor: 3.885

2.  Will the ubiquitin system furnish as many drug targets as protein kinases?

Authors:  Philip Cohen; Marianna Tcherpakov
Journal:  Cell       Date:  2010-11-24       Impact factor: 41.582

3.  Protein-protein interactions: Interactome under construction.

Authors:  Laura Bonetta
Journal:  Nature       Date:  2010-12-09       Impact factor: 49.962

Review 4.  Pharmaceutical R&D in the spotlight: why is there still unmet medical need?

Authors:  Esther F Schmid; Dennis A Smith
Journal:  Drug Discov Today       Date:  2007-10-23       Impact factor: 7.851

5.  Spending on new drug development1.

Authors:  Christopher Paul Adams; Van Vu Brantner
Journal:  Health Econ       Date:  2010-02       Impact factor: 3.046

Review 6.  The exploration of macrocycles for drug discovery--an underexploited structural class.

Authors:  Edward M Driggers; Stephen P Hale; Jinbo Lee; Nicholas K Terrett
Journal:  Nat Rev Drug Discov       Date:  2008-07       Impact factor: 84.694

7.  Too many roads not taken.

Authors:  Aled M Edwards; Ruth Isserlin; Gary D Bader; Stephen V Frye; Timothy M Willson; Frank H Yu
Journal:  Nature       Date:  2011-02-10       Impact factor: 49.962

8.  The art of the chemical probe.

Authors:  Stephen V Frye
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

Review 9.  Activity-based probes: discovering new biology and new drug targets.

Authors:  William P Heal; T H Tam Dang; Edward W Tate
Journal:  Chem Soc Rev       Date:  2010-10-01       Impact factor: 54.564

Review 10.  Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Authors:  Lynn Bedford; James Lowe; Lawrence R Dick; R John Mayer; James E Brownell
Journal:  Nat Rev Drug Discov       Date:  2010-12-10       Impact factor: 84.694
View more
  64 in total

1.  Translational informatics: an industry perspective.

Authors:  Michael N Cantor
Journal:  J Am Med Inform Assoc       Date:  2012-01-11       Impact factor: 4.497

2.  Drug discovery: Chemical beauty contest.

Authors:  Paul Leeson
Journal:  Nature       Date:  2012-01-25       Impact factor: 49.962

Review 3.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

4.  How chemoproteomics can enable drug discovery and development.

Authors:  Raymond E Moellering; Benjamin F Cravatt
Journal:  Chem Biol       Date:  2012-01-27

5.  Predicting the in vivo mechanism of action for drug leads using NMR metabolomics.

Authors:  Steven Halouska; Robert J Fenton; Raúl G Barletta; Robert Powers
Journal:  ACS Chem Biol       Date:  2011-12-01       Impact factor: 5.100

6.  2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

Authors:  Véronique Hamon; Raphael Bourgeas; Pierre Ducrot; Isabelle Theret; Laura Xuereb; Marie Jeanne Basse; Jean Michel Brunel; Sebastien Combes; Xavier Morelli; Philippe Roche
Journal:  J R Soc Interface       Date:  2013-11-06       Impact factor: 4.118

7.  Know your target, know your molecule.

Authors:  Mark E Bunnage; Adam M Gilbert; Lyn H Jones; Erik C Hett
Journal:  Nat Chem Biol       Date:  2015-06       Impact factor: 15.040

Review 8.  An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Authors:  Michael J Waring; John Arrowsmith; Andrew R Leach; Paul D Leeson; Sam Mandrell; Robert M Owen; Garry Pairaudeau; William D Pennie; Stephen D Pickett; Jibo Wang; Owen Wallace; Alex Weir
Journal:  Nat Rev Drug Discov       Date:  2015-06-19       Impact factor: 84.694

9.  Preclinical target validation using patient-derived cells.

Authors:  Aled M Edwards; Cheryl H Arrowsmith; Chas Bountra; Mark E Bunnage; Marc Feldmann; Julian C Knight; Dhavalkumar D Patel; Panagiotis Prinos; Michael D Taylor; Michael Sundström
Journal:  Nat Rev Drug Discov       Date:  2015-02-20       Impact factor: 84.694

Review 10.  Applications of chemogenomic library screening in drug discovery.

Authors:  Lyn H Jones; Mark E Bunnage
Journal:  Nat Rev Drug Discov       Date:  2017-01-20       Impact factor: 84.694
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.