Literature DB >> 25978985

Know your target, know your molecule.

Mark E Bunnage1, Adam M Gilbert2, Lyn H Jones1, Erik C Hett1.   

Abstract

Mesh：

Year:  2015        PMID： 25978985     DOI： 10.1038/nchembio.1813

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  27 in total

1.  Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Authors:  Paul Morgan; Piet H Van Der Graaf; John Arrowsmith; Doug E Feltner; Kira S Drummond; Craig D Wegner; Steve D A Street
Journal:  Drug Discov Today       Date:  2011-12-29       Impact factor: 7.851

2.  Functional interrogation of the kinome using nucleotide acyl phosphates.

Authors:  Matthew P Patricelli; A Katrin Szardenings; Marek Liyanage; Tyzoon K Nomanbhoy; Min Wu; Helge Weissig; Arwin Aban; Doris Chun; Stephen Tanner; John W Kozarich
Journal:  Biochemistry       Date:  2007-01-16       Impact factor: 3.162

3.  Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.

Authors:  Michael S Lopez; Jonathan W Choy; Ulf Peters; Martin L Sos; David O Morgan; Kevan M Shokat
Journal:  J Am Chem Soc       Date:  2013-11-20       Impact factor: 15.419

4.  Getting pharmaceutical R&D back on target.

Authors:  Mark E Bunnage
Journal:  Nat Chem Biol       Date:  2011-06       Impact factor: 15.040

5.  Chemical biology: Greasy tags for protein removal.

Authors:  Taavi K Neklesa; Craig M Crews
Journal:  Nature       Date:  2012-07-18       Impact factor: 49.962

6.  Tracking cancer drugs in living cells by thermal profiling of the proteome.

Authors:  Mikhail M Savitski; Friedrich B M Reinhard; Holger Franken; Thilo Werner; Maria Fälth Savitski; Dirk Eberhard; Daniel Martinez Molina; Rozbeh Jafari; Rebecca Bakszt Dovega; Susan Klaeger; Bernhard Kuster; Pär Nordlund; Marcus Bantscheff; Gerard Drewes
Journal:  Science       Date:  2014-10-02       Impact factor: 47.728

7.  Chemistry: Chemical con artists foil drug discovery.

Authors:  Jonathan Baell; Michael A Walters
Journal:  Nature       Date:  2014-09-25       Impact factor: 49.962

8.  Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.

Authors:  Marcus Bantscheff; Carsten Hopf; Mikhail M Savitski; Antje Dittmann; Paola Grandi; Anne-Marie Michon; Judith Schlegl; Yann Abraham; Isabelle Becher; Giovanna Bergamini; Markus Boesche; Manja Delling; Birgit Dümpelfeld; Dirk Eberhard; Carola Huthmacher; Toby Mathieson; Daniel Poeckel; Valérie Reader; Katja Strunk; Gavain Sweetman; Ulrich Kruse; Gitte Neubauer; Nigel G Ramsden; Gerard Drewes
Journal:  Nat Biotechnol       Date:  2011-01-23       Impact factor: 54.908

9.  Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Authors:  Kay Ahn; Sarah E Smith; Marya B Liimatta; David Beidler; Nalini Sadagopan; David T Dudley; Tim Young; Paul Wren; Yanhua Zhang; Steven Swaney; Keri Van Becelaere; Jacqueline L Blankman; Daniel K Nomura; Shobha N Bhattachar; Cory Stiff; Tyzoon K Nomanbhoy; Eranthie Weerapana; Douglas S Johnson; Benjamin F Cravatt
Journal:  J Pharmacol Exp Ther       Date:  2011-04-19       Impact factor: 4.030

10.  Structural basis for the design of selective phosphodiesterase 4B inhibitors.

Authors:  David Fox; Alex B Burgin; Mark E Gurney
Journal:  Cell Signal       Date:  2013-12-19       Impact factor: 4.315
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  26 in total

Review 1.  Functional genomics to uncover drug mechanism of action.

Authors:  Sebastian M B Nijman
Journal:  Nat Chem Biol       Date:  2015-11-17       Impact factor: 15.040

Review 2.  Advances in targeting 'undruggable' transcription factors with small molecules.

Authors:  Matthew J Henley; Angela N Koehler
Journal:  Nat Rev Drug Discov       Date:  2021-05-18       Impact factor: 84.694

3.  Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor.

Authors:  Aruna Wijeratne; Junpeng Xiao; Christopher Reutter; Kelly W Furness; Rebecca Leon; Mohammad Zia-Ebrahimi; Rachel N Cavitt; John M Strelow; Robert D Van Horn; Sheng-Bin Peng; David A Barda; Thomas A Engler; Michael J Chalmers
Journal:  ACS Med Chem Lett       Date:  2018-05-21       Impact factor: 4.345

4.  Development of inverse electron demand Diels-Alder ligation and TR-FRET assays for the determination of ligand-protein target occupancy in live cells.

Authors:  Jasmina Marjanovic; Aleksandra Baranczak; Violeta Marin; Henning Stockmann; Paul L Richardson; Anil Vasudevan
Journal:  Medchemcomm       Date:  2017-02-21       Impact factor: 3.597

5.  New Chemical Modalities and Strategic Thinking in Early Drug Discovery.

Authors:  Maria-Jesus Blanco; Kevin M Gardinier
Journal:  ACS Med Chem Lett       Date:  2020-01-14       Impact factor: 4.345

Review 6.  Non-kinase targets of protein kinase inhibitors.

Authors:  Lenka Munoz
Journal:  Nat Rev Drug Discov       Date:  2017-03-10       Impact factor: 84.694

Review 7.  PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future.

Authors:  Mariell Pettersson; Craig M Crews
Journal:  Drug Discov Today Technol       Date:  2019-02-13

8.  Impact of a five-dimensional framework on R&D productivity at AstraZeneca.

Authors:  Paul Morgan; Dean G Brown; Simon Lennard; Mark J Anderton; J Carl Barrett; Ulf Eriksson; Mark Fidock; Bengt Hamrén; Anthony Johnson; Ruth E March; James Matcham; Jerome Mettetal; David J Nicholls; Stefan Platz; Steve Rees; Michael A Snowden; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2018-01-19       Impact factor: 84.694

9.  Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity.

Authors:  Andrei Ursu; Jessica L Childs-Disney; Alicia J Angelbello; Matthew G Costales; Samantha M Meyer; Matthew D Disney
Journal:  ACS Chem Biol       Date:  2020-07-09       Impact factor: 5.100

10.  CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.

Authors:  Andrew D Cansfield; Tammy Ladduwahetty; Mihiro Sunose; Katie Ellard; Rosemary Lynch; Anthea L Newton; Ann Lewis; Gavin Bennett; Nico Zinn; Douglas W Thomson; Anne J Rüger; John T Feutrill; Oliver Rausch; Alan P Watt; Giovanna Bergamini
Journal:  ACS Med Chem Lett       Date:  2016-06-10       Impact factor: 4.345
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