Literature DB >> 22281594

Drug discovery: Chemical beauty contest.

Paul Leeson.   

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Year:  2012        PMID: 22281594     DOI: 10.1038/481455a

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


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  10 in total

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2.  A comparison of physiochemical property profiles of development and marketed oral drugs.

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3.  Assessment of the consistency of medicinal chemists in reviewing sets of compounds.

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Review 4.  The influence of the 'organizational factor' on compound quality in drug discovery.

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5.  Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

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Journal:  ACS Chem Neurosci       Date:  2010-03-25       Impact factor: 4.418

6.  Quantifying the chemical beauty of drugs.

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Review 7.  The influence of drug-like concepts on decision-making in medicinal chemistry.

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8.  Physiochemical drug properties associated with in vivo toxicological outcomes.

Authors:  Jason D Hughes; Julian Blagg; David A Price; Simon Bailey; Gary A Decrescenzo; Rajesh V Devraj; Edmund Ellsworth; Yvette M Fobian; Michael E Gibbs; Richard W Gilles; Nigel Greene; Enoch Huang; Teresa Krieger-Burke; Jens Loesel; Travis Wager; Larry Whiteley; Yao Zhang
Journal:  Bioorg Med Chem Lett       Date:  2008-07-24       Impact factor: 2.823

9.  Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.

Authors:  Tim Luker; Lilian Alcaraz; Kamaldeep K Chohan; Niklas Blomberg; Dearg S Brown; Roger J Butlin; Thomas Elebring; Andrew M Griffin; Simon Guile; Stephen St-Gallay; Britt-Marie Swahn; Steve Swallow; Michael J Waring; Mark C Wenlock; Paul D Leeson
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10.  Getting pharmaceutical R&D back on target.

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3.  Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds.

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4.  Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2.

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5.  Stacking with No Planarity?

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6.  Designing of phenol-based β-carbonic anhydrase1 inhibitors through QSAR, molecular docking, and MD simulation approach.

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7.  Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Authors:  Alan R Jacobson; Michael Adler; Nicholas R Silvaggi; Karen N Allen; Genessa M Smith; Ross A Fredenburg; Ross L Stein; Jong-Beak Park; Xiaochuan Feng; Charles B Shoemaker; Sharad S Deshpande; Michael C Goodnough; Carl J Malizio; Eric A Johnson; Sabine Pellett; William H Tepp; Saul Tzipori
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8.  Accessing Elaborated 2,1-Borazaronaphthalene Cores Using Photoredox/Nickel Dual-Catalytic Functionalization.

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9.  Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

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Review 10.  Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives.

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