Yoshiyuki Kita1,2, Ritsuko Kita3,4, Ai Nitta3,4, Chiaki Nishimura5, Goji Tomita3,4. 1. Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan. yoshiyuki.kita@med.toho-u.ac.jp. 2. Department of Ophthalmology, Toho University, Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan. yoshiyuki.kita@med.toho-u.ac.jp. 3. Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan. 4. Department of Ophthalmology, Toho University, Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan. 5. Department of Medical Informatics, Toho University School of Medicine, Tokyo, Japan.
Abstract
PURPOSE: To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes. METHODS: Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses. RESULTS: In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (r = -0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (r = 0.38-0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (r = 0.425-0.809). CONCLUSIONS: From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present.
PURPOSE: To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes. METHODS: Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses. RESULTS: In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (r = -0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (r = 0.38-0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (r = 0.425-0.809). CONCLUSIONS: From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present.
Authors: Delia Bendschneider; Ralf P Tornow; Folkert K Horn; Robert Laemmer; Christopher W Roessler; Anselm G Juenemann; Friedrich E Kruse; Christian Y Mardin Journal: J Glaucoma Date: 2010-09 Impact factor: 2.503
Authors: Gadi Wollstein; Joel S Schuman; Lori L Price; Ali Aydin; Siobahn A Beaton; Paul C Stark; James G Fujimoto; Hiroshi Ishikawa Journal: Am J Ophthalmol Date: 2004-08 Impact factor: 5.258
Authors: Anna A Ledolter; Matthias Monhart; Andreas Schoetzau; Margarita G Todorova; Anja M Palmowski-Wolfe Journal: Doc Ophthalmol Date: 2015-01-24 Impact factor: 2.379
Authors: Xunda Luo; Nimesh B Patel; Lakshmi P Rajagopalan; Ronald S Harwerth; Laura J Frishman Journal: Invest Ophthalmol Vis Sci Date: 2014-06-26 Impact factor: 4.799
Authors: Erica Bresciani-Battilana; Ivan C Teixeira; Diego T Q Barbosa; Cristiano Caixeta-Umbelino; Maurício D Paolera; Niro Kasahara Journal: Int Ophthalmol Date: 2014-09-03 Impact factor: 2.031
Authors: Ivan C Teixeira; Erica Bresciani-Battilana; Diego T Q Barbosa; Cristiano Caixeta-Umbelino; Maurício D Paolera; Niro Kasahara Journal: Int Ophthalmol Date: 2014-11-26 Impact factor: 2.031