PURPOSE: To correlate multifocal electroretinogram (mfERG) findings in the macular area of glaucoma patients with automated perimetry (visual fields) and with optical coherence tomography (OCT). METHODS: A two-global flash mfERG (VERIS™) was recorded in 20 eyes with primary open-angle glaucoma. The root mean square was calculated, and three response epochs were analysed: the direct component (15-45 ms) and two induced components (IC-1 at 45-75 ms and IC-2 at 75-105 ms). The central 10° of the mfERG was compared to the central 10° of the OCT and of the visual field. Responses grouped in a superior and in an inferior semicircle, extending between 10° and 20°, were also compared to the corresponding areas of the OCT and of the visual fields. In addition, the area of the papillomacular bundle was also analysed separately. RESULTS: In glaucoma patients, mfERG responses showed a significant positive association with retinal thickness in the central 10° for IC2 (p = 0.001) and a trend for IC1 (p = 0.066). A significant association was found between the central IC1 and IC2 of the mfERG and corresponding perimetric sensitivities expressed in linear units (p < 0.01). The OCT showed a positive association with visual field sensitivities (p < 0.05) in all areas examined (p < 0.05). Separation of the papillomacular bundle area did not improve structure-function association further. CONCLUSIONS: In our study, mfERG showed a statistically significant correlation with perimetric sensitivity measured in linear units and with structural macular changes detected with time-domain OCT.
PURPOSE: To correlate multifocal electroretinogram (mfERG) findings in the macular area of glaucomapatients with automated perimetry (visual fields) and with optical coherence tomography (OCT). METHODS: A two-global flash mfERG (VERIS™) was recorded in 20 eyes with primary open-angle glaucoma. The root mean square was calculated, and three response epochs were analysed: the direct component (15-45 ms) and two induced components (IC-1 at 45-75 ms and IC-2 at 75-105 ms). The central 10° of the mfERG was compared to the central 10° of the OCT and of the visual field. Responses grouped in a superior and in an inferior semicircle, extending between 10° and 20°, were also compared to the corresponding areas of the OCT and of the visual fields. In addition, the area of the papillomacular bundle was also analysed separately. RESULTS: In glaucomapatients, mfERG responses showed a significant positive association with retinal thickness in the central 10° for IC2 (p = 0.001) and a trend for IC1 (p = 0.066). A significant association was found between the central IC1 and IC2 of the mfERG and corresponding perimetric sensitivities expressed in linear units (p < 0.01). The OCT showed a positive association with visual field sensitivities (p < 0.05) in all areas examined (p < 0.05). Separation of the papillomacular bundle area did not improve structure-function association further. CONCLUSIONS: In our study, mfERG showed a statistically significant correlation with perimetric sensitivity measured in linear units and with structural macular changes detected with time-domain OCT.
Authors: Felipe A Medeiros; Linda M Zangwill; Christopher Bowd; Roberto M Vessani; Remo Susanna; Robert N Weinreb Journal: Am J Ophthalmol Date: 2005-01 Impact factor: 5.258
Authors: Livia M Brandao; Matthias Monhart; Andreas Schötzau; Anna A Ledolter; Anja M Palmowski-Wolfe Journal: Doc Ophthalmol Date: 2017-06-07 Impact factor: 2.379
Authors: Lívia M Brandão; Matthias Monhart; Andreas Schötzau; Anna A Ledolter; Anja M Palmowski-Wolfe Journal: J Ophthalmol Date: 2017-11-07 Impact factor: 1.909
Authors: Livia M Brandao; Anna A Ledolter; Matthias Monhart; Andreas Schötzau; Anja M Palmowski-Wolfe Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-08-04 Impact factor: 3.117