BACKGROUND: Biologic implants have been recommended for reinforcement in routine and challenging hernia repair. However, experimental and clinical studies have reported adverse effects (e.g., slow implant integration and pronounced foreign body reaction). To evaluate the impact of different material processing methods (cross-linking vs. non-cross-linking of collagen) and implant design, four different biologic hernia implants were compared directly in experimental intraperitoneal onlay mesh plasty (IPOM). Tissue integration, shrinkage, and foreign body reaction were primary outcome parameters. METHODS: In this study, 48 Sprague-Dawley rats were randomized to four treatment groups. Open IPOM repair was performed. One peritoneal defect per animal was covered with 2 × 2 cm patches of cross-linked or non-cross-linked implants including CollaMend (n = 12), Peripatch (n = 12), Surgisis (n = 12), and Tutomesh (n = 12). In half of the animals, fibrin sealant was applied for additional fixation and to cover sutures. The observation period was 60 days. The primary outcome parameters were implant integration, shrinkage, and foreign body reaction. Macroscopic and histologic assessments were performed. RESULTS: The integration of implants was insufficient in all the groups. The implants could be detached easily from the underlying tissue, and the penetration of fibroblasts and vessels was limited to the perforations. Foreign body reaction was pronounced with CollaMend and Surgisis, leading to persistent granulomatous inflammation. Shrinkage was excessive with Surgisis, whereas Tutomesh and Peripatch yielded sufficient anti-adhesion and elicited no foreign body reaction. CONCLUSION: At 2 months, cross-linked and non-cross-linked biologic hernia implants were poorly integrated. Cross-linking led to a more pronounced foreign body reaction. Less inflammatory response may reduce local complications, but did not enhance implant integration in this study.
BACKGROUND: Biologic implants have been recommended for reinforcement in routine and challenging hernia repair. However, experimental and clinical studies have reported adverse effects (e.g., slow implant integration and pronounced foreign body reaction). To evaluate the impact of different material processing methods (cross-linking vs. non-cross-linking of collagen) and implant design, four different biologic hernia implants were compared directly in experimental intraperitoneal onlay mesh plasty (IPOM). Tissue integration, shrinkage, and foreign body reaction were primary outcome parameters. METHODS: In this study, 48 Sprague-Dawley rats were randomized to four treatment groups. Open IPOM repair was performed. One peritoneal defect per animal was covered with 2 × 2 cm patches of cross-linked or non-cross-linked implants including CollaMend (n = 12), Peripatch (n = 12), Surgisis (n = 12), and Tutomesh (n = 12). In half of the animals, fibrin sealant was applied for additional fixation and to cover sutures. The observation period was 60 days. The primary outcome parameters were implant integration, shrinkage, and foreign body reaction. Macroscopic and histologic assessments were performed. RESULTS: The integration of implants was insufficient in all the groups. The implants could be detached easily from the underlying tissue, and the penetration of fibroblasts and vessels was limited to the perforations. Foreign body reaction was pronounced with CollaMend and Surgisis, leading to persistent granulomatous inflammation. Shrinkage was excessive with Surgisis, whereas Tutomesh and Peripatch yielded sufficient anti-adhesion and elicited no foreign body reaction. CONCLUSION: At 2 months, cross-linked and non-cross-linked biologic hernia implants were poorly integrated. Cross-linking led to a more pronounced foreign body reaction. Less inflammatory response may reduce local complications, but did not enhance implant integration in this study.
Authors: S Gruber-Blum; A H Petter-Puchner; K Mika; J Brand; H Redl; W Ohlinger; T Benesch; R H Fortelny Journal: Surg Endosc Date: 2010-05-29 Impact factor: 4.584
Authors: Luca Ansaloni; Paolo Cambrini; Fausto Catena; Salomone Di Saverio; Stefano Gagliardi; Filippo Gazzotti; Jason P Hodde; Dennis W Metzger; Luigi D'Alessandro; Antonio Daniele Pinna Journal: J Invest Surg Date: 2007 Jul-Aug Impact factor: 2.533
Authors: F Catena; L Ansaloni; A Leone; A De Cataldis; S Gagliardi; F Gazzotti; S Peruzzi; S Agrusti; L D'Alessandro; M Taffurelli Journal: Hernia Date: 2004-09-10 Impact factor: 4.739
Authors: Alexander H Petter-Puchner; Nadja Walder; Heinz Redl; Robert Schwab; Wolfgang Ohlinger; Simone Gruber-Blum; René H Fortelny Journal: J Surg Res Date: 2008-01-31 Impact factor: 2.192
Authors: M Ditzel; E B Deerenberg; N Grotenhuis; J J Harlaar; K Monkhorst; Y M Bastiaansen-Jenniskens; J Jeekel; J F Lange Journal: Surg Endosc Date: 2013-04-03 Impact factor: 4.584