Literature DB >> 21519832

Electronic medical records and personalized medicine.

Mark A Hoffman1, Marc S Williams.   

Abstract

If the dream of personalized medicine is to be realized, tremendous amounts of data specific to each individual must be captured, synthesized and presented to clinicians at the time this information is needed to make care decisions for the patient. This can only be accomplished through the use of sophisticated electronic medical record (EMR) systems that are designed to support this function. This article will define two important aspects of a fully functional EMR the ability to: present patients or clinicians with high quality context specific information at the point of care (so-called "just-in time" education) and to combine clinically relevant information from disparate sources in order to guide the clinician to the optimized intervention for a given patient (clinical decision support). Personalized medicine examples are used to illustrate these concepts. As implemented most EMR systems are not being used to assimilate the information needed to provide personalized medicine. A description of necessary enhancements to currently available systems that will be needed to create a "personalized medicine enabled" EMR is provided.

Entities:  

Mesh:

Year:  2011        PMID: 21519832     DOI: 10.1007/s00439-011-0992-y

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  26 in total

1.  Clinical reasoning: the relative contribution of identification, interpretation and hypothesis errors to misdiagnosis.

Authors:  Michele Groves; Peter O'Rourke; Heather Alexander
Journal:  Med Teach       Date:  2003-11       Impact factor: 3.650

2.  A cognitive perspective on medical expertise: theory and implication.

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Journal:  Acad Med       Date:  1990-10       Impact factor: 6.893

3.  The application of computer-based tools in obtaining the genetic family history.

Authors:  Monica A Giovanni; Michael F Murray
Journal:  Curr Protoc Hum Genet       Date:  2010-07

Review 4.  The genome-enabled electronic medical record.

Authors:  M A Hoffman
Journal:  J Biomed Inform       Date:  2006-03-15       Impact factor: 6.317

5.  Adaptive learning via selectionism and Bayesianism, Part I: connection between the two.

Authors:  Jun Zhang
Journal:  Neural Netw       Date:  2009-04-05

Review 6.  Becoming a medical information master: feeling good about not knowing everything.

Authors:  D C Slawson; A F Shaughnessy; J H Bennett
Journal:  J Fam Pract       Date:  1994-05       Impact factor: 0.493

7.  The proliferation of scientific literature: a natural process.

Authors:  J M Ziman
Journal:  Science       Date:  1980-04-25       Impact factor: 47.728

8.  Analysis of questions asked by family doctors regarding patient care.

Authors:  J W Ely; J A Osheroff; M H Ebell; G R Bergus; B T Levy; M L Chambliss; E R Evans
Journal:  BMJ       Date:  1999-08-07

9.  HIV genotypic resistance testing to optimize antiretroviral prescribing: is there room for improvement?

Authors:  Jonathan Uy; John T Brooks; Rose Baker; Mark Hoffman; Anne Moorman; Richard Novak
Journal:  Antivir Ther       Date:  2007

10.  Information management to enable personalized medicine: stakeholder roles in building clinical decision support.

Authors:  Gregory J Downing; Scott N Boyle; Kristin M Brinner; Jerome A Osheroff
Journal:  BMC Med Inform Decis Mak       Date:  2009-10-08       Impact factor: 2.796

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  28 in total

1.  Evaluation: A Qualitative Pilot Study of Novel Information Technology Infrastructure to Communicate Genetic Variant Updates.

Authors:  Stephanie Klinkenberg-Ramirez; Pamela M Neri; Lynn A Volk; Sara J Samaha; Lisa P Newmark; Stephanie Pollard; Matthew Varugheese; Samantha Baxter; Samuel J Aronson; Heidi L Rehm; David W Bates
Journal:  Appl Clin Inform       Date:  2016-06-01       Impact factor: 2.342

Review 2.  Clinical decision support for genetically guided personalized medicine: a systematic review.

Authors:  Brandon M Welch; Kensaku Kawamoto
Journal:  J Am Med Inform Assoc       Date:  2012-08-25       Impact factor: 4.497

3.  Utility of gene-specific algorithms for predicting pathogenicity of uncertain gene variants.

Authors:  David K Crockett; Elaine Lyon; Marc S Williams; Scott P Narus; Julio C Facelli; Joyce A Mitchell
Journal:  J Am Med Inform Assoc       Date:  2011-10-28       Impact factor: 4.497

Review 4.  Building the foundation for genomics in precision medicine.

Authors:  Samuel J Aronson; Heidi L Rehm
Journal:  Nature       Date:  2015-10-15       Impact factor: 49.962

Review 5.  Integrating pharmacogenomics into electronic health records with clinical decision support.

Authors:  J Kevin Hicks; Henry M Dunnenberger; Karl F Gumpper; Cyrine E Haidar; James M Hoffman
Journal:  Am J Health Syst Pharm       Date:  2016-12-01       Impact factor: 2.637

6.  Evaluation of a novel electronic genetic screening and clinical decision support tool in prenatal clinical settings.

Authors:  Emily A Edelman; Bruce K Lin; Teresa Doksum; Brian Drohan; Vaughn Edelson; Siobhan M Dolan; Kevin Hughes; James O'Leary; Lisa Vasquez; Sara Copeland; Shelley L Galvin; Nicole DeGroat; Setul Pardanani; W Gregory Feero; Claire Adams; Renee Jones; Joan Scott
Journal:  Matern Child Health J       Date:  2014-07

7.  Perceptions of Personalized Medicine in an Academic Health System: Educational Findings.

Authors:  Allison Vorderstrasse; Sara Huston Katsanis; Mollie A Minear; Nancy Yang; Tejinder Rakhra-Burris; Jason W Reeves; Robert Cook-Deegan; Geoffrey S Ginsburg; Leigh Ann Simmons
Journal:  J Contemp Med Educ       Date:  2015

8.  User-centered design of multi-gene sequencing panel reports for clinicians.

Authors:  Elizabeth Cutting; Meghan Banchero; Amber L Beitelshees; James J Cimino; Guilherme Del Fiol; Ayse P Gurses; Mark A Hoffman; Linda Jo Bone Jeng; Kensaku Kawamoto; Mark Kelemen; Harold Alan Pincus; Alan R Shuldiner; Marc S Williams; Toni I Pollin; Casey Lynnette Overby
Journal:  J Biomed Inform       Date:  2016-07-14       Impact factor: 6.317

9.  Personalized medicine: challenges and opportunities for translational bioinformatics.

Authors:  Casey Lynnette Overby; Peter Tarczy-Hornoch
Journal:  Per Med       Date:  2013-07-01       Impact factor: 2.512

Review 10.  Leveraging the electronic health record to implement genomic medicine.

Authors:  Iftikhar J Kullo; Gail P Jarvik; Teri A Manolio; Marc S Williams; Dan M Roden
Journal:  Genet Med       Date:  2012-09-27       Impact factor: 8.822

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