Eun-Kyu Kim1, Woo Chul Noh, Wonshik Han, Dong-Young Noh. 1. Department of Surgery and Breast Cancer Center, Korea Institute of Radiological and Medical Sciences, Korea Cancer Center Hospital, and Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea.
Abstract
BACKGROUND: Young age is regarded as an adverse prognostic factor in patients with breast cancer, especially in those with a hormone receptor (HR)-positive tumor. We investigated the prognostic significance of an age of <35 years stratified by molecular subtype based on HR and HER2. METHODS: Two large databases of Korean breast cancer patients, which included nationwide registry data, were analyzed. RESULTS: In an analysis of 2,474 patients from the single institution, an age of <35 years was found to be an independent predictor of recurrence in patients with HR+/HER2- (hazard ratio 1.87; 95% confidence interval [CI]: 1.11-3.14; P=0.018), HR+/HER2+ (hazard ratio 3.09; 95% CI: 1.19-8.03; P=0.020), and HR-/HER2+ (hazard ratio 2.01; 95% CI: 1.03-3.92; P=0.040) subtypes, but not in those with the HR-/HER2- (triple-negative, TN) subtype (hazard ratio 1.08; 95% CI: 0.60-1.95; P=0.802). The results of an analysis of nationwide database data on 31,672 patients also showed that an age of <35 years significantly predicted poor cancer-specific survival in patients with HR+/HER2- (hazard ratio 3.40; 95% CI: 2.41-4.82; P<0.001), HR+/HER2+ (hazard ratio 1.96; 95% CI: 1.23-3.12; P=0.005), and HR-/HER2+ (hazard ratio 1.65; 95% CI: 1.07-2.52; P=0.022) subtypes, but again not in those with the TN subtype (hazard ratio 1.21; 95% CI: 0.88-1.67; P=0.240). CONCLUSION: The prognostic significance of young age was found to depend on molecular subtype. An age of <35 years was a poor prognosticator in patients with the HR+/HER2-, HR+/HER2+, and HR-/HER2+ subtypes, but not in those with the TN subtype.
BACKGROUND: Young age is regarded as an adverse prognostic factor in patients with breast cancer, especially in those with a hormone receptor (HR)-positive tumor. We investigated the prognostic significance of an age of <35 years stratified by molecular subtype based on HR and HER2. METHODS: Two large databases of Korean breast cancerpatients, which included nationwide registry data, were analyzed. RESULTS: In an analysis of 2,474 patients from the single institution, an age of <35 years was found to be an independent predictor of recurrence in patients with HR+/HER2- (hazard ratio 1.87; 95% confidence interval [CI]: 1.11-3.14; P=0.018), HR+/HER2+ (hazard ratio 3.09; 95% CI: 1.19-8.03; P=0.020), and HR-/HER2+ (hazard ratio 2.01; 95% CI: 1.03-3.92; P=0.040) subtypes, but not in those with the HR-/HER2- (triple-negative, TN) subtype (hazard ratio 1.08; 95% CI: 0.60-1.95; P=0.802). The results of an analysis of nationwide database data on 31,672 patients also showed that an age of <35 years significantly predicted poor cancer-specific survival in patients with HR+/HER2- (hazard ratio 3.40; 95% CI: 2.41-4.82; P<0.001), HR+/HER2+ (hazard ratio 1.96; 95% CI: 1.23-3.12; P=0.005), and HR-/HER2+ (hazard ratio 1.65; 95% CI: 1.07-2.52; P=0.022) subtypes, but again not in those with the TN subtype (hazard ratio 1.21; 95% CI: 0.88-1.67; P=0.240). CONCLUSION: The prognostic significance of young age was found to depend on molecular subtype. An age of <35 years was a poor prognosticator in patients with the HR+/HER2-, HR+/HER2+, and HR-/HER2+ subtypes, but not in those with the TN subtype.
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