Literature DB >> 21293363

Drug discovery: A question of library design.

Philip J Hajduk, Warren R J D Galloway, David R Spring.   

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Year:  2011        PMID： 21293363     DOI： 10.1038/470042a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  9 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

Review 2.  Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection.

Authors:  Edgar Jacoby; Ansgar Schuffenhauer; Maxim Popov; Kamal Azzaoui; Benjamin Havill; Ulrich Schopfer; Caroline Engeloch; Jaroslav Stanek; Pierre Acklin; Pascal Rigollier; Friederike Stoll; Guido Koch; Peter Meier; David Orain; Rudolph Giger; Jürgen Hinrichs; Karine Malagu; Jürg Zimmermann; Hans-Joerg Roth
Journal:  Curr Top Med Chem       Date:  2005       Impact factor: 3.295

Review 3.  Fragment-based lead discovery: a chemical update.

Authors:  Daniel A Erlanson
Journal:  Curr Opin Biotechnol       Date:  2006-11-03       Impact factor: 9.740

4.  Puzzling through fragment-based drug design.

Authors:  Philip J Hajduk
Journal:  Nat Chem Biol       Date:  2006-12       Impact factor: 15.040

Review 5.  A decade of fragment-based drug design: strategic advances and lessons learned.

Authors:  Philip J Hajduk; Jonathan Greer
Journal:  Nat Rev Drug Discov       Date:  2007-02-09       Impact factor: 84.694

Review 6.  The influence of drug-like concepts on decision-making in medicinal chemistry.

Authors:  Paul D Leeson; Brian Springthorpe
Journal:  Nat Rev Drug Discov       Date:  2007-11       Impact factor: 84.694

7.  Organic chemistry: Molecular diversity by design.

Authors:  Stuart L Schreiber
Journal:  Nature       Date:  2009-01-08       Impact factor: 49.962

8.  Discovering high-affinity ligands for proteins.

Authors:  P J Hajduk; R P Meadows; S W Fesik
Journal:  Science       Date:  1997-10-17       Impact factor: 47.728

9.  Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.

Authors:  Simone Di Micco; Romina Vitale; Maurizio Pellecchia; Michele F Rega; Renata Riva; Andrea Basso; Giuseppe Bifulco
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446
  9 in total
  29 in total

Review 1.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

2.  Medicinal chemistry for 2020.

Authors:  Seetharama D Satyanarayanajois; Ronald A Hill
Journal:  Future Med Chem       Date:  2011-10       Impact factor: 3.808

Review 3.  From laptop to benchtop to bedside: structure-based drug design on protein targets.

Authors:  Lu Chen; John K Morrow; Hoang T Tran; Sharangdhar S Phatak; Lei Du-Cuny; Shuxing Zhang
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

4.  The importance of molecular complexity in the design of screening libraries.

Authors:  Shahul H Nilar; Ngai Ling Ma; Thomas H Keller
Journal:  J Comput Aided Mol Des       Date:  2013-09       Impact factor: 3.686

5.  Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV).

Authors:  Aurelio Bonavia; Michael Franti; Erin Pusateri Keaney; Kelli Kuhen; Mohindra Seepersaud; Branko Radetich; Jian Shao; Ayako Honda; Janetta Dewhurst; Kara Balabanis; James Monroe; Karen Wolff; Colin Osborne; Leanne Lanieri; Keith Hoffmaster; Jakal Amin; Judit Markovits; Michelle Broome; Elizabeth Skuba; Ivan Cornella-Taracido; Gerard Joberty; Tewis Bouwmeester; Lawrence Hamann; John A Tallarico; Ruben Tommasi; Teresa Compton; Simon M Bushell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-18       Impact factor: 11.205

Review 6.  Protein-protein interaction modulators: advances, successes and remaining challenges.

Authors:  Lloyd Mabonga; Abidemi Paul Kappo
Journal:  Biophys Rev       Date:  2019-07-12

7.  Dark chemical matter in public screening assays and derivation of target hypotheses.

Authors:  Swarit Jasial; Jürgen Bajorath
Journal:  Medchemcomm       Date:  2017-10-26       Impact factor: 3.597

8.  Drug discovery: nature's pieces.

Authors:  Brian K Shoichet
Journal:  Nat Chem       Date:  2013-01       Impact factor: 24.427

9.  Translational synthetic chemistry.

Authors:  Sarathy Kesavan; Lisa A Marcaurelle
Journal:  Nat Chem Biol       Date:  2013-04       Impact factor: 15.040

Review 10.  Oncogenic protein interfaces: small molecules, big challenges.

Authors:  Tracy L Nero; Craig J Morton; Jessica K Holien; Jerome Wielens; Michael W Parker
Journal:  Nat Rev Cancer       Date:  2014-03-13       Impact factor: 60.716
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