Literature DB >> 21248841

The Polycomb complex PRC2 and its mark in life.

Raphaël Margueron1, Danny Reinberg.   

Abstract

Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21248841      PMCID： PMC3760771          DOI： 10.1038/nature09784

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  97 in total

1.  Genome-wide evolutionary analysis of eukaryotic DNA methylation.

Authors:  Assaf Zemach; Ivy E McDaniel; Pedro Silva; Daniel Zilberman
Journal:  Science       Date:  2010-04-15       Impact factor: 47.728

2.  Suz12 binds to silenced regions of the genome in a cell-type-specific manner.

Authors:  Sharon L Squazzo; Henriette O'Geen; Vitalina M Komashko; Sheryl R Krig; Victor X Jin; Sung-wook Jang; Raphael Margueron; Danny Reinberg; Roland Green; Peggy J Farnham
Journal:  Genome Res       Date:  2006-06-02       Impact factor: 9.043

Review 3.  Facultative heterochromatin: is there a distinctive molecular signature?

Authors:  Patrick Trojer; Danny Reinberg
Journal:  Mol Cell       Date:  2007-10-12       Impact factor: 17.970

Review 4.  H3K27 demethylases, at long last.

Authors:  Tomek Swigut; Joanna Wysocka
Journal:  Cell       Date:  2007-10-05       Impact factor: 41.582

5.  Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

Authors:  Kyoko L Yap; Side Li; Ana M Muñoz-Cabello; Selina Raguz; Lei Zeng; Shiraz Mujtaba; Jesús Gil; Martin J Walsh; Ming-Ming Zhou
Journal:  Mol Cell       Date:  2010-06-11       Impact factor: 17.970

6.  Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.

Authors:  Urmi Savla; Judith Benes; Junyu Zhang; Richard S Jones
Journal:  Development       Date:  2008-01-23       Impact factor: 6.868

7.  Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

Authors:  I-Hsin Su; Ashwin Basavaraj; Andrew N Krutchinsky; Oliver Hobert; Axel Ullrich; Brian T Chait; Alexander Tarakhovsky
Journal:  Nat Immunol       Date:  2002-12-23       Impact factor: 25.606

8.  SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

Authors:  Ru Cao; Yi Zhang
Journal:  Mol Cell       Date:  2004-07-02       Impact factor: 17.970

9.  Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.

Authors:  Mitsuhiro Endoh; Takaho A Endo; Tamie Endoh; Yu-ichi Fujimura; Osamu Ohara; Tetsuro Toyoda; Arie P Otte; Masaki Okano; Neil Brockdorff; Miguel Vidal; Haruhiko Koseki
Journal:  Development       Date:  2008-03-13       Impact factor: 6.868

10.  Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.

Authors:  Maxim Nekrasov; Tetyana Klymenko; Sven Fraterman; Bernadett Papp; Katarzyna Oktaba; Thomas Köcher; Adrian Cohen; Hendrik G Stunnenberg; Matthias Wilm; Jürg Müller
Journal:  EMBO J       Date:  2007-08-30       Impact factor: 11.598
View more
  1395 in total

Review 1.  The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Authors:  Ali Shilatifard
Journal:  Annu Rev Biochem       Date:  2012       Impact factor: 23.643

Review 2.  The roles and regulation of Polycomb complexes in neural development.

Authors:  Matthew Corley; Kristen L Kroll
Journal:  Cell Tissue Res       Date:  2014-11-01       Impact factor: 5.249

Review 3.  Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.

Authors:  Chiara Mozzetta; Julien Pontis; Slimane Ait-Si-Ali
Journal:  Antioxid Redox Signal       Date:  2014-12-19       Impact factor: 8.401

4.  ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.

Authors:  Hua Li; Benjamin G Bitler; Vinod Vathipadiekal; Marie E Maradeo; Michael Slifker; Caretha L Creasy; Peter J Tummino; Paul Cairns; Michael J Birrer; Rugang Zhang
Journal:  Cancer Prev Res (Phila)       Date:  2011-12-05

5.  An E3 ligase complex regulates SET-domain polycomb group protein activity in Arabidopsis thaliana.

Authors:  Cheol Woong Jeong; Hyungmin Roh; Tuong Vi Dang; Yang Do Choi; Robert L Fischer; Jong Seob Lee; Yeonhee Choi
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-25       Impact factor: 11.205

6.  Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Authors:  Patricia Santofimia-Castaño; Bruno Rizzuti; Ángel L Pey; Philippe Soubeyran; Miguel Vidal; Raúl Urrutia; Juan L Iovanna; José L Neira
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-18       Impact factor: 11.205

7.  Interferon-γ resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis.

Authors:  Priya Londhe; Judith K Davie
Journal:  Sci Signal       Date:  2013-12-10       Impact factor: 8.192

8.  Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.

Authors:  Aditi Qamra; Tsz Wai Chu; Mélanie Criqui; Monika Sharma; Julissa Tsao; Danielle A Henry; Dalia Barsyte-Lovejoy; Cheryl H Arrowsmith; Neil Winegarden; Mathieu Lupien; Lea Harrington
Journal:  Elife       Date:  2020-04-16       Impact factor: 8.140

9.  Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells.

Authors:  Lingzhi Li; Ping Qiu; Bailing Chen; Yongju Lu; Kai Wu; Chitra Thakur; Qingshan Chang; Jiaying Sun; Fei Chen
Journal:  Toxicol Appl Pharmacol       Date:  2014-02-25       Impact factor: 4.219

10.  PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.

Authors:  Idan Cohen; Dejian Zhao; Carmit Bar; Victor J Valdes; Katherine L Dauber-Decker; Minh Binh Nguyen; Manabu Nakayama; Michael Rendl; Wendy A Bickmore; Haruhiko Koseki; Deyou Zheng; Elena Ezhkova
Journal:  Cell Stem Cell       Date:  2018-05-03       Impact factor: 24.633
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.