Literature DB >> 12496962

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

I-Hsin Su1, Ashwin Basavaraj, Andrew N Krutchinsky, Oliver Hobert, Axel Ullrich, Brian T Chait, Alexander Tarakhovsky.   

Abstract

Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Using Cre-mediated conditional mutagenesis, we demonstrated a critical role for Ezh2 in early B cell development and rearrangement of the immunoglobulin heavy chain gene (Igh). We also revealed Ezh2 as a key regulator of histone H3 methylation in early B cell progenitors. Our data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development.

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Year:  2002        PMID： 12496962     DOI： 10.1038/ni876

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  270 in total

1.  An analysis of the gene expression program of mammalian neural progenitor cells.

Authors:  F J Livesey; T L Young; C L Cepko
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-20       Impact factor: 11.205

2.  B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.

Authors:  Kristen Johnson; David L Pflugh; Duonan Yu; David G T Hesslein; Kuo-I Lin; Alfred L M Bothwell; Andrei Thomas-Tikhonenko; David G Schatz; Kathryn Calame
Journal:  Nat Immunol       Date:  2004-07-18       Impact factor: 25.606

3.  Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.

Authors:  Eric J Perkins; Barbara L Kee; Dale A Ramsden
Journal:  Nucleic Acids Res       Date:  2004-03-29       Impact factor: 16.971

Review 4.  Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms.

Authors:  Su-Jiang Zhang; Omar Abdel-Wahab
Journal:  Curr Hematol Malig Rep       Date:  2012-03       Impact factor: 3.952

5.  EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.

Authors:  Irina Velichutina; Rita Shaknovich; Huimin Geng; Nathalie A Johnson; Randy D Gascoyne; Ari M Melnick; Olivier Elemento
Journal:  Blood       Date:  2010-08-24       Impact factor: 22.113

6.  Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.

Authors:  Lifeng Wang; Qihuang Jin; Ji-Eun Lee; I-hsin Su; Kai Ge
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

7.  Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Authors:  Damian B Yap; Justin Chu; Tobias Berg; Matthieu Schapira; S-W Grace Cheng; Annie Moradian; Ryan D Morin; Andrew J Mungall; Barbara Meissner; Merrill Boyle; Victor E Marquez; Marco A Marra; Randy D Gascoyne; R Keith Humphries; Cheryl H Arrowsmith; Gregg B Morin; Samuel A J R Aparicio
Journal:  Blood       Date:  2010-12-29       Impact factor: 22.113

8.  Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Authors:  Wen Hao Neo; Christopher A G Booth; Emanuele Azzoni; Lijun Chi; Paul Delgado-Olguín; Marella F T R de Bruijn; Sten Eirik W Jacobsen; Adam J Mead
Journal:  Blood       Date:  2018-03-19       Impact factor: 22.113

9.  Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis.

Authors:  Yongfeng Liu; Junjie Peng; Tongyu Sun; Ni Li; Le Zhang; Jiale Ren; Huairui Yuan; Shan Kan; Qiang Pan; Xiang Li; Yufeng Ding; Min Jiang; Xiaoji Cong; Minjia Tan; Yushui Ma; Da Fu; Sanjun Cai; Yichuan Xiao; Xiaoming Wang; Jun Qin
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

10.  Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

Authors:  Sandhya R Pulivarthy; Mattia Lion; Guray Kuzu; Adam G W Matthews; Mark L Borowsky; John Morris; Robert E Kingston; Jonathan H Dennis; Michael Y Tolstorukov; Marjorie A Oettinger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205
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