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Literature DB >> 17936700

Facultative heterochromatin: is there a distinctive molecular signature?

Abstract

The Latin word "facultas" literally means "opportunity." Facultative heterochromatin (fHC) then designates genomic regions in the nucleus of a eukaryotic cell that have the opportunity to adopt open or compact conformations within temporal and spatial contexts. This review focuses on the molecular and functional aspects of fHC that distinguish it from constitutive heterochromatin (cHC) and euchromatin (EC) and discusses various concepts regarding the regulation of fHC structure. We begin by revisiting the historical developments that gave rise to our current appreciation of fHC.

Mesh：

Substances：
Heterochromatin
Histones

Year: 2007 PMID： 17936700 DOI： 10.1016/j.molcel.2007.09.011

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

199 in total

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Journal: J Biol Chem Date: 2018-12-04 Impact factor: 5.157

2. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer.

Authors: Sandra Baumgart; Elisabeth Glesel; Garima Singh; Nai-Ming Chen; Kristina Reutlinger; Jinsan Zhang; Daniel D Billadeau; Martin E Fernandez-Zapico; Thomas M Gress; Shiv K Singh; Volker Ellenrieder
Journal: Gastroenterology Date: 2011-11-10 Impact factor: 22.682

Review 10. EZH2: not EZHY (easy) to deal.

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Journal: Mol Cancer Res Date: 2014-02-13 Impact factor: 5.852

Facultative heterochromatin: is there a distinctive molecular signature?

1. Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.

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