Literature DB >> 21199792

Long intergenic noncoding RNAs: new links in cancer progression.

Miao-Chih Tsai1, Robert C Spitale, Howard Y Chang.   

Abstract

The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.
© 2011 AACR.

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Year:  2011        PMID： 21199792      PMCID： PMC3057914          DOI： 10.1158/0008-5472.CAN-10-2483

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  41 in total

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  336 in total

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