| Literature DB >> 20673990 |
Maite Huarte1, Mitchell Guttman, David Feldser, Manuel Garber, Magdalena J Koziol, Daniela Kenzelmann-Broz, Ahmad M Khalil, Or Zuk, Ido Amit, Michal Rabani, Laura D Attardi, Aviv Regev, Eric S Lander, Tyler Jacks, John L Rinn.
Abstract
Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association with hnRNP-K. This interaction is required for proper genomic localization of hnRNP-K at repressed genes and regulation of p53 mediates apoptosis. We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20673990 PMCID： PMC2956184 DOI： 10.1016/j.cell.2010.06.040
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582