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Literature DB >> 22094949

Non-coding RNAs in human disease.

Abstract

The relevance of the non-coding genome to human disease has mainly been studied in the context of the widespread disruption of microRNA (miRNA) expression and function that is seen in human cancer. However, we are only beginning to understand the nature and extent of the involvement of non-coding RNAs (ncRNAs) in disease. Other ncRNAs, such as PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), transcribed ultraconserved regions (T-UCRs) and large intergenic non-coding RNAs (lincRNAs) are emerging as key elements of cellular homeostasis. Along with microRNAs, dysregulation of these ncRNAs is being found to have relevance not only to tumorigenesis, but also to neurological, cardiovascular, developmental and other diseases. There is great interest in therapeutic strategies to counteract these perturbations of ncRNAs.

Entities: Disease Species

Mesh：

Substances：
RNA, Untranslated

Year: 2011 PMID： 22094949 DOI： 10.1038/nrg3074

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

147 in total

Review 1. MicroRNAs: small RNAs with a big role in gene regulation.

Authors: Lin He; Gregory J Hannon
Journal: Nat Rev Genet Date: 2004-07 Impact factor: 53.242

Review 2. The widespread regulation of microRNA biogenesis, function and decay.

Authors: Jacek Krol; Inga Loedige; Witold Filipowicz
Journal: Nat Rev Genet Date: 2010-07-27 Impact factor: 53.242

3. Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome.

Authors: Sole Gatto; Floriana Della Ragione; Amelia Cimmino; Maria Strazzullo; Muller Fabbri; Margherita Mutarelli; Lorenzo Ferraro; Alessandro Weisz; Maurizio D'Esposito; Maria R Matarazzo
Journal: Epigenetics Date: 2010-07-01 Impact factor: 4.528

4. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Authors: P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; Hans Stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
Journal: Cell Date: 2006-03-24 Impact factor: 41.582

5. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

Authors: Vincent Boissonneault; Isabelle Plante; Serge Rivest; Patrick Provost
Journal: J Biol Chem Date: 2008-11-05 Impact factor: 5.157

6. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

Authors: Mohammad Ali Faghihi; Farzaneh Modarresi; Ahmad M Khalil; Douglas E Wood; Barbara G Sahagan; Todd E Morgan; Caleb E Finch; Georges St Laurent; Paul J Kenny; Claes Wahlestedt
Journal: Nat Med Date: 2008-06-29 Impact factor: 53.440

Review 7. Mechanisms of imprinting of the Prader-Willi/Angelman region.

Authors: Bernhard Horsthemke; Joseph Wagstaff
Journal: Am J Med Genet A Date: 2008-08-15 Impact factor: 2.802

8. The transcriptional landscape of the mammalian genome.

Authors: P Carninci; T Kasukawa; S Katayama; J Gough; M C Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; V B Bajic; S E Brenner; S Batalov; A R R Forrest; M Zavolan; M J Davis; L G Wilming; V Aidinis; J E Allen; A Ambesi-Impiombato; R Apweiler; R N Aturaliya; T L Bailey; M Bansal; L Baxter; K W Beisel; T Bersano; H Bono; A M Chalk; K P Chiu; V Choudhary; A Christoffels; D R Clutterbuck; M L Crowe; E Dalla; B P Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; C F Fletcher; T Fukushima; M Furuno; S Futaki; M Gariboldi; P Georgii-Hemming; T R Gingeras; T Gojobori; R E Green; S Gustincich; M Harbers; Y Hayashi; T K Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; K Ikeo; A Iwama; T Ishikawa; M Jakt; A Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; G Kollias; S P T Krishnan; A Kruger; S K Kummerfeld; I V Kurochkin; L F Lareau; D Lazarevic; L Lipovich; J Liu; S Liuni; S McWilliam; M Madan Babu; M Madera; L Marchionni; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Y Okazaki; V Orlando; K C Pang; W J Pavan; G Pavesi; G Pesole; N Petrovsky; S Piazza; J Reed; J F Reid; B Z Ring; M Ringwald; B Rost; Y Ruan; S L Salzberg; A Sandelin; C Schneider; C Schönbach; K Sekiguchi; C A M Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; E Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; S L Tan; S Tang; M S Taylor; J Tegner; S A Teichmann; H R Ueda; E van Nimwegen; R Verardo; C L Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; W Hide; C Bult; S M Grimmond; R D Teasdale; E T Liu; V Brusic; J Quackenbush; C Wahlestedt; J S Mattick; D A Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; M Itoh; T Kato; H Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; K Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
Journal: Science Date: 2005-09-02 Impact factor: 47.728

9. Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer.

Authors: Jipei Liao; Lei Yu; Yuping Mei; Maria Guarnera; Jun Shen; Ruiyun Li; Zhenqiu Liu; Feng Jiang
Journal: Mol Cancer Date: 2010-07-27 Impact factor: 27.401

10. A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference.

Authors: Yanjie Lu; Jiening Xiao; Huixian Lin; Yunlong Bai; Xiaobin Luo; Zhiguo Wang; Baofeng Yang
Journal: Nucleic Acids Res Date: 2009-01-09 Impact factor: 16.971

1880 in total

Review 1. RNA Structural Differentiation: Opportunities with Pattern Recognition.

Authors: Christopher S Eubanks; Amanda E Hargrove
Journal: Biochemistry Date: 2018-12-18 Impact factor: 3.162

Review 2. MicroRNAs, wild-type and mutant p53: more questions than answers.

Authors: Matthew Jones; Ashish Lal
Journal: RNA Biol Date: 2012-06-01 Impact factor: 4.652

3. miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Authors: Ruozhen Hu; Dominique A Kagele; Thomas B Huffaker; Marah C Runtsch; Margaret Alexander; Jin Liu; Erin Bake; Wei Su; Matthew A Williams; Dinesh S Rao; Thomas Möller; Gwenn A Garden; June L Round; Ryan M O'Connell
Journal: Immunity Date: 2014-10-16 Impact factor: 31.745

4. Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma.

Authors: Youtao Xu; Jie Wang; Mantang Qiu; Lei Xu; Ming Li; Feng Jiang; Rong Yin; Lin Xu
Journal: Tumour Biol Date: 2014-10-31

Review 5. Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.

Authors: Mary McMahon; Adrian Contreras; Davide Ruggero
Journal: Wiley Interdiscip Rev RNA Date: 2014-10-31 Impact factor: 9.957

6. Role of TRPV4 in matrix stiffness-induced expression of EMT-specific LncRNA.

Authors: Shweta Sharma; Li Ma; Shaik O Rahaman
Journal: Mol Cell Biochem Date: 2020-07-30 Impact factor: 3.396

Review 7. MicroRNAs in mucosal inflammation.

Authors: Viola Neudecker; Xiaoyi Yuan; Jessica L Bowser; Holger K Eltzschig
Journal: J Mol Med (Berl) Date: 2017-07-20 Impact factor: 4.599