Literature DB >> 21076194

Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency.

Uwe Titt1, Dragan Mirkovic, Gabriel O Sawakuchi, Luis A Perles, Wayne D Newhauser, Phillip J Taddei, Radhe Mohan.   

Abstract

In scanned-beam proton therapy, the beam spot properties, such as the lateral and longitudinal size and the minimum achievable range, are influenced by beam optics, scattering media and drift spaces in the treatment unit. Currently available spot scanning systems offer few options for adjusting these properties. We investigated a method for adjusting the lateral and longitudinal spot size that utilizes downstream plastic pre-absorbers located near a water phantom. The spot size adjustment was characterized using Monte Carlo simulations of a modified commercial scanned-beam treatment head. Our results revealed that the pre-absorbers can be used to reduce the lateral full width at half maximum (FWHM) of dose spots in water by up to 14 mm, and to increase the longitudinal extent from about 1 mm to 5 mm at residual ranges of 4 cm and less. A large factor in manipulating the lateral spot sizes is the drift space between the pre-absorber and the water phantom. Increasing the drift space from 0 cm to 15 cm leads to an increase in the lateral FWHM from 2.15 cm to 2.87 cm, at a water-equivalent depth of 1 cm. These findings suggest that this spot adjustment method may improve the quality of spot-scanned proton treatments.

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Year:  2010        PMID: 21076194      PMCID: PMC3001334          DOI: 10.1088/0031-9155/55/23/S10

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  21 in total

1.  A compact ridge filter for spread out Bragg peak production in pulsed proton clinical beams.

Authors:  V Kostjuchenko; D Nichiporov; V Luckjashin
Journal:  Med Phys       Date:  2001-07       Impact factor: 4.071

2.  Ridge filter design for proton therapy at Hyogo Ion Beam Medical Center.

Authors:  Takashi Akagi; Akio Higashi; Hironobu Tsugami; Hidenobu Sakamoto; Yasutaka Masuda; Yoshio Hishikawa
Journal:  Phys Med Biol       Date:  2003-11-21       Impact factor: 3.609

3.  The PSI Gantry 2: a second generation proton scanning gantry.

Authors:  Eros Pedroni; Ralph Bearpark; Terence Böhringer; Adolf Coray; Jürgen Duppich; Sven Forss; David George; Martin Grossmann; Gudrun Goitein; Christian Hilbes; Martin Jermann; Shixiong Lin; Antony Lomax; Marco Negrazus; Marco Schippers; Goran Kotle
Journal:  Z Med Phys       Date:  2004       Impact factor: 4.820

4.  Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams.

Authors:  E Pedroni; S Scheib; T Böhringer; A Coray; M Grossmann; S Lin; A Lomax
Journal:  Phys Med Biol       Date:  2005-02-07       Impact factor: 3.609

5.  Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams.

Authors:  Wayne Newhauser; Nicholas Koch; Stephen Hummel; Matthias Ziegler; Uwe Titt
Journal:  Phys Med Biol       Date:  2005-10-24       Impact factor: 3.609

6.  Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: a Monte Carlo study.

Authors:  M Bues; W D Newhauser; U Titt; A R Smith
Journal:  Radiat Prot Dosimetry       Date:  2005       Impact factor: 0.972

7.  Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams.

Authors:  Gabriel O Sawakuchi; Uwe Titt; Dragan Mirkovic; George Ciangaru; X Ronald Zhu; Narayan Sahoo; Michael T Gillin; Radhe Mohan
Journal:  Phys Med Biol       Date:  2010-01-13       Impact factor: 3.609

8.  Beam optics design of compact gantry for proton therapy.

Authors:  E Pedroni; H Enge
Journal:  Med Biol Eng Comput       Date:  1995-05       Impact factor: 2.602

9.  The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization.

Authors:  E Pedroni; R Bacher; H Blattmann; T Böhringer; A Coray; A Lomax; S Lin; G Munkel; S Scheib; U Schneider
Journal:  Med Phys       Date:  1995-01       Impact factor: 4.071

10.  Spot scanning system for proton radiotherapy.

Authors:  T Kanai; K Kawachi; Y Kumamoto; H Ogawa; T Yamada; H Matsuzawa; T Inada
Journal:  Med Phys       Date:  1980 Jul-Aug       Impact factor: 4.071

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  10 in total

Review 1.  The physics of proton therapy.

Authors:  Wayne D Newhauser; Rui Zhang
Journal:  Phys Med Biol       Date:  2015-03-24       Impact factor: 3.609

2.  Dosimetric Comparison of Various Spot Placement Techniques in Proton Pencil Beam Scanning.

Authors:  Mahboob Ur Rehman; Omar A Zeidan; Twyla Willoughby; Sanford L Meeks; Patrick Kelly; Kevin Erhart
Journal:  Int J Part Ther       Date:  2022-01-31

3.  Preliminary evaluation of multifield and single-field optimization for the treatment planning of spot-scanning proton therapy of head and neck cancer.

Authors:  Enzhuo M Quan; Wei Liu; Richard Wu; Yupeng Li; Steven J Frank; Xiaodong Zhang; X Ronald Zhu; Radhe Mohan
Journal:  Med Phys       Date:  2013-08       Impact factor: 4.071

4.  The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy.

Authors:  Yue Li; Yunzhe Gao; Xinguo Liu; Jian Shi; Jiawen Xia; Jiancheng Yang; Lijun Mao
Journal:  PLoS One       Date:  2021-04-01       Impact factor: 3.240

5.  Reducing the cost of proton radiation therapy: the feasibility of a streamlined treatment technique for prostate cancer.

Authors:  Wayne D Newhauser; Rui Zhang; Timothy G Jones; Annelise Giebeler; Phillip J Taddei; Robert D Stewart; Andrew Lee; Oleg Vassiliev
Journal:  Cancers (Basel)       Date:  2015-04-24       Impact factor: 6.639

6.  Validation and clinical implementation of an accurate Monte Carlo code for pencil beam scanning proton therapy.

Authors:  Sheng Huang; Minglei Kang; Kevin Souris; Christopher Ainsley; Timothy D Solberg; James E McDonough; Charles B Simone; Liyong Lin
Journal:  J Appl Clin Med Phys       Date:  2018-07-30       Impact factor: 2.102

7.  The potential of Gantry beamline large momentum acceptance for real time tumour tracking in pencil beam scanning proton therapy.

Authors:  Giovanni Fattori; Ye Zhang; David Meer; Damien Charles Weber; Antony John Lomax; Sairos Safai
Journal:  Sci Rep       Date:  2020-09-18       Impact factor: 4.379

8.  Small spot size versus large spot size: Effect on plan quality for lung cancer in pencil beam scanning proton therapy.

Authors:  Suresh Rana; Anatoly B Rosenfeld
Journal:  J Appl Clin Med Phys       Date:  2022-01-06       Impact factor: 2.102

9.  What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy.

Authors:  Chie Toramatsu; Norio Katoh; Shinichi Shimizu; Hideaki Nihongi; Taeko Matsuura; Seishin Takao; Naoki Miyamoto; Ryusuke Suzuki; Kenneth Sutherland; Rumiko Kinoshita; Rikiya Onimaru; Masayori Ishikawa; Kikuo Umegaki; Hiroki Shirato
Journal:  Radiat Oncol       Date:  2013-03-05       Impact factor: 3.481

10.  Applications of various range shifters for proton pencil beam scanning radiotherapy.

Authors:  Haibo Lin; Chengyu Shi; Sheng Huang; Jiajian Shen; Minglei Kang; Qing Chen; Huifang Zhai; James McDonough; Zelig Tochner; Curtiland Deville; Charles B Simone; Stefan Both
Journal:  Radiat Oncol       Date:  2021-08-06       Impact factor: 3.481

  10 in total

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