| Literature DB >> 20961978 |
Sami Hocine1, Robert H Singer, David Grünwald.
Abstract
Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.Entities:
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Year: 2010 PMID: 20961978 PMCID: PMC2982171 DOI: 10.1101/cshperspect.a000752
Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN: 1943-0264 Impact factor: 10.005