| Literature DB >> 23720759 |
Carolina Eliscovich1, Adina R Buxbaum, Zachary B Katz, Robert H Singer.
Abstract
Cells have evolved to regulate the asymmetric distribution of specific mRNA targets to institute spatial and temporal control over gene expression. Over the last few decades, evidence has mounted as to the importance of localization elements in the mRNA sequence and their respective RNA-binding proteins. Live imaging methodologies have shown mechanistic details of this phenomenon. In this minireview, we focus on the advanced biochemical and cell imaging techniques used to tweeze out the finer aspects of mechanisms of mRNA movement.Keywords: 3′-UTR; Fluorescence; Gene Expression; In Vivo Imaging; Localization Element/Zipcode; RNA Transport; RNA-Protein Interaction; RNA-binding Proteins; mRNA; β-Actin mRNA
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Year: 2013 PMID： 23720759 PMCID： PMC3711302 DOI： 10.1074/jbc.R113.452094
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157