| Literature DB >> 20919812 |
Per-Erik Johanson1, Anne Marie Fenstad, Ove Furnes, Göran Garellick, Leif I Havelin, Sören Overgaard, Alma B Pedersen, Johan Kärrholm.
Abstract
BACKGROUND ANDEntities:
Mesh:
Year: 2010 PMID: 20919812 PMCID: PMC3214740 DOI: 10.3109/17453674.2010.525193
Source DB: PubMed Journal: Acta Orthop ISSN: 1745-3674 Impact factor: 3.717
The total study group of 174,192 THA patients up to 73 years of age (those with femoral fractures excluded) who were operated 1995 through 2007
| HRA | THA | p-value | |
|---|---|---|---|
| n = 1,638 | n = 172,554 | ||
| Percentage males | 68 | 43 | < 0.001 |
| Mean age, years (range) | 51 (15–73) | 62 (12–73) | < 0.001 |
| Age groups, % | |||
| < 30 | 2.1 | 0.6 | |
| 30–39 | 8.9 | 1.8 | |
| 40–49 | 31 | 6.1 | |
| 50–59 | 42 | 23 | |
| 60–74 | 17 | 69 | < 0.001 |
| Operated side, % (no.) | |||
| Right | 53 (861) | 54 (93,866) | 0.1 |
| Diagnosis, % | |||
| Primary osteoarthritis | 89 | 85 | |
| Inflammatory arthritis | 2.2 | 4.3 | |
| Childhood diseases | 6.5 | 6.1 | |
| Idiopathic femoral head necrosis | 0.9 | 2.7 | |
| Other | 1.0 | 2.1 | < 0.001 |
Chi-squared test.
Non-parametric.
HRA implant designs in the NARA database, 1995–2007
| Implant design | % | n |
|---|---|---|
| BHR | 48 | 780 |
| Durom | 21 | 344 |
| ASR | 18 | 296 |
| ReCap | 12 | 191 |
| Adept | 0.9 | 14 |
| Cormet (+/- HA) | 0.4 | 7 |
| McMinn | 0.4 | 6 |
| Total | 1,638 |
Unadjusted revision rates and reasons for aseptic revision up to 2 years
| HRA | THA | p-value | |
|---|---|---|---|
| n=1,638 | n=172,554 | ||
| Crude aseptic revision rate, % (no.) | |||
| 1 year | 1.6 (26) | 0.7 (1251) | |
| 2 years | 2.4 (40) | 1.1 (1954) | |
| Kaplan-Meier unadjusted non-septic cumulative revision rate, % (95% CI) | |||
| 1 year | 1.8 (1.1–2.4) | 0.8 (0.7–0.8) | |
| 2 years | 3.3 (2.2–4.3) | 1.2 (1.2–1.3) | < 0.001 |
| Reason for revision up to 2 years, % (no.) | |||
| Aseptic loosening | 25 (10) | 25 (497) | |
| Fracture | 40 (16) | 9 (176) | |
| Dislocation | 0 | 50 (967) | |
| Pain only | 5 (2) | 4 (88) | |
| Other | 30 (12) | 12 (226) | < 0.001 |
Log-rank test.
Chi-squared test.
Figure 1.Unadjusted Kaplan-Meier-estimated cumulative survival (CS ± 1.96 SE) for 1,638 HRAs with estimated 2-year CS of 96.7% (95% CI: 95.7–97.8; no. remaining = 547) and 172,554 THAs with estimated 2-year CS of 98.8% (95% CI: 98.7–98.8; no. remaining = 135,173); p < 0.001 (log-rank test).
Age- and sex-stratified relative risk of aseptic revision within 2 years after primary operation. HRA was compared to all other types of conventional THA or only to the all-cemented (all-c THA) subpopulation. Data are based on a Cox regression model adjusted for operated side, nationality, diagnosis, and type of implant
| Adjusted revision risk (95% CI) | Number of cases (No. of revisions) | ||||||
|---|---|---|---|---|---|---|---|
| HRA/THA | p-value | HRA/all-c THA | p-value | HRA | THA | all-c THA | |
| Age < 50 years | |||||||
| Males | 1.9 (1.0–3.9) | 0.07 | 2.4 (1.1–5.3) | 0.04 | 460 (9) | 7,183 (109) | 1,782 (18) |
| Females | 4.7 (2.6–8.5) | < 0.001 | 7.4 (3.7–15) | < 0.001 | 221 (13) | 7,486 (114) | 2,242 (21) |
| Age 50–73 years | |||||||
| Males | 1.7 (0.9–3.1) | 0.1 | 2.1 (1.1–3.9) | 0.02 | 653 (10) | 67,134 (807) | 43,725 (387) |
| Females | 3.2 (1.6–6.5) | 0.001 | 4.0 (2.0–8.1) | < 0.001 | 304 (8) | 90,751 (924) | 64,308 (482) |
Relative risk of aseptic revision up to 2 years (RR) with 95% confidence interval (CI) in 1,611 hip resurfacings (35 revisions). Data are based on a Cox regression model including age (< 50 or ≥ 50 years), sex, diagnosis, hospital production volume, and the 4 most common HRA designs with BHR as reference
| RR | 95% CI | p-value | |
|---|---|---|---|
| Hospital production volume: | |||
| < 70 / ≥ 70 procedures | 3.7 | 1.5–8.9 | 0.003 |
| Hip resurfacing design: | |||
| BHR (reference) | 1 | – | 0.02 |
| Durom | 3.1 | 1.2–7.8 | 0.02 |
| ASR | 2.7 | 1.0–7.4 | 0.06 |
| ReCap | 5.4 | 1.8–16 | 0.003 |
| Male / female | 0.5 | 0.2–0.9 | 0.03 |
| Age (< 50 / 50–73 years) | 1.5 | 0.8–3.1 | 0.2 |
| Primary / secondary OA | 1.0 | 0.4–2.8 | 0.9 |
The same type of analysis as in Table 5 except that femoral head diameter (categorized as ≤ 44mm, 45–49 mm, 50–54 mm, and ≥ 55 mm) has been added, resulting in 1,552 hip resurfacings (35 revisions) available for analysis
| RR | 95% CI | p-value | |
|---|---|---|---|
| Hospital production volume: | |||
| < 70 / ≥ 70 procedures | 3.7 | 1.5–8.8 | 0.004 |
| Hip resurfacing design: | |||
| BHR (reference) | 1 | – | 0.02 |
| Durom | 3.1 | 1.2–7.8 | 0.02 |
| ASR | 2.3 | 0.8–6.5 | 0.1 |
| ReCap | 5.4 | 1.8–17 | 0.003 |
| Male / female | 0.7 | 0.3–1.8 | 0.5 |
| Femoral head diameter | |||
| < 44 mm (reference) | 1 | – | 0.3 |
| 45–49 mm | 0.8 | 0.3–2.4 | 0.8 |
| 50–54 mm | 0.4 | 0.1–1.4 | 0.2 |
| > 55 mm | 0.9 | 0.2–4.2 | 0.9 |
| Age (< 50 / 50–73 years) | 1.4 | 0.7–3.0 | 0.3 |
| Primary / secondary OA | 1.2 | 0.4–3.4 | 0.7 |
Figure 2.Unadjusted Kaplan-Meier-estimated cumulative survival (CS) of the group of the 4 most common types of HRA, subgroups with significant influence on early non-septic revision rate (CS ± 1.96SE). A. Hospital with ≥ 70 HRAs: n = 820, 2-year CS = 98.8% (95% CI: 97.9–99.8; no. remaining at 2 years = 269). Hospital with < 70 HRA: n = 791, 2-year CS = 95.5% (95% CI: 93.7–97.2; no. remaining at 2 years = 272); p < 0.001 (log-rank test). B. BHR: n = 780, 2-year CS = 98.8% (95% CI: 97.9–99.7; no. remaining at 2 years = 341). Non-BHR: n = 831, 2-year CS = 95.6% (95% CI: 93.8–97.3; no. remaining at 2 years = 200); p < 0.001 (log-rank test).