Literature DB >> 20878475

Novel single nucleotide polymorphism identification in interleukin-6 gene of Pakistani sheep.

Safdar Ali1, Masroor Ellahi Babar, A Hossain Farid, Pervez Akhtar, Ali Raza Awan.   

Abstract

The present study aimed to identify single-nucleotide polymorphism (SNP) in coding and non-coding regions of interleukin-6 (IL-6) gene of Pakistani sheep. The IL-6 gene of 205 animals from nine sheep breeds were sequenced for screening of SNP. Characterizing the IL-6 gene revealed thirteen SNP sites within the intronic region of IL-6 gene. The novel SNPs found in the present study can serve as genetic marker for association studies with susceptibility/resistance to parasite infection in sheep. This is first report of SNP polymorphism of IL-6 gene of Pakistani sheep.

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Year:  2010        PMID： 20878475     DOI： 10.1007/s11033-010-0342-5

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


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