Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

Literature DB >> 20837755

Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

Jeffrey B Locke¹, Gracia Morales, Mark Hilgers, Kedar G C, Shahad Rahawi, Juan José Picazo, Karen Joy Shaw, Jeffrey L Stein.

Abstract

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of ≤ 2 μg/ml.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20837755 PMCID： PMC2981277 DOI： 10.1128/AAC.00714-10

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

24 in total

1. Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.

Authors: Nicole Wolter; Anthony M Smith; David J Farrell; William Schaffner; Matthew Moore; Cynthia G Whitney; James H Jorgensen; Keith P Klugman
Journal: Antimicrob Agents Chemother Date: 2005-08 Impact factor: 5.191

2. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid.

Authors: R D Gonzales; P C Schreckenberger; M B Graham; S Kelkar; K DenBesten; J P Quinn
Journal: Lancet Date: 2001-04-14 Impact factor: 79.321

3. The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics.

Authors: Katherine S Long; Jacob Poehlsgaard; Corinna Kehrenberg; Stefan Schwarz; Birte Vester
Journal: Antimicrob Agents Chemother Date: 2006-07 Impact factor: 5.191

4. Linezolid resistance in a clinical isolate of Staphylococcus aureus.

Authors: S Tsiodras; H S Gold; G Sakoulas; G M Eliopoulos; C Wennersten; L Venkataraman; R C Moellering; M J Ferraro
Journal: Lancet Date: 2001-07-21 Impact factor: 79.321

5. IS21-558 insertion sequences are involved in the mobility of the multiresistance gene cfr.

Authors: Corinna Kehrenberg; Frank M Aarestrup; Stefan Schwarz
Journal: Antimicrob Agents Chemother Date: 2006-12-04 Impact factor: 5.191

6. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri.

Authors: S Schwarz; C Werckenthin; C Kehrenberg
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

7. Improved method for electroporation of Staphylococcus aureus.

Authors: S Schenk; R A Laddaga
Journal: FEMS Microbiol Lett Date: 1992-07-01 Impact factor: 2.742

8. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.

Authors: Seok-Ming Toh; Liqun Xiong; Cesar A Arias; Maria V Villegas; Karen Lolans; John Quinn; Alexander S Mankin
Journal: Mol Microbiol Date: 2007-06 Impact factor: 3.501

9. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

Authors: Jeffrey B Locke; Mark Hilgers; Karen Joy Shaw
Journal: Antimicrob Agents Chemother Date: 2009-10-05 Impact factor: 5.191

10. Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.

Authors: Venkata G Meka; Satish K Pillai; George Sakoulas; Christine Wennersten; Lata Venkataraman; Paola C DeGirolami; George M Eliopoulos; Robert C Moellering; Howard S Gold
Journal: J Infect Dis Date: 2004-06-09 Impact factor: 5.226

35 in total

Review 1. Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors: Katherine S Long; Birte Vester
Journal: Antimicrob Agents Chemother Date: 2011-12-05 Impact factor: 5.191

Review 2. Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors: Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal: Clin Microbiol Rev Date: 2012-07 Impact factor: 26.132

3. Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.

Authors: Jeffrey B Locke; Douglas E Zuill; Caitlyn R Scharn; Jennifer Deane; Daniel F Sahm; Gerald A Denys; Richard V Goering; Karen J Shaw
Journal: Antimicrob Agents Chemother Date: 2014-08-25 Impact factor: 5.191

4. Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.

Authors: Rasmus N Klitgaard; Eleni Ntokou; Katrine Nørgaard; Daniel Biltoft; Lykke H Hansen; Nicolai M Trædholm; Jacob Kongsted; Birte Vester
Journal: Antimicrob Agents Chemother Date: 2015-04-06 Impact factor: 5.191

5. Ribosomal protein L3 mutations are associated with cfr-mediated linezolid resistance in clinical isolates of Staphylococcus cohnii.

Authors: Hongtao Xu; Rui Tian; Yanming Li; Dongke Chen; Yalin Liu; Yunjian Hu; Fei Xiao
Journal: Curr Microbiol Date: 2015-03-01 Impact factor: 2.188

6. The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.

Authors: Jacqueline LaMarre; Rodrigo E Mendes; Teresa Szal; Stefan Schwarz; Ronald N Jones; Alexander S Mankin
Journal: Antimicrob Agents Chemother Date: 2012-12-17 Impact factor: 5.191