Literature DB >> 19805557

Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

Jeffrey B Locke1, Mark Hilgers, Karen Joy Shaw.   

Abstract

Following recent reports of ribosomal protein L3 mutations in laboratory-derived linezolid-resistant (LZD(r)) Staphylococcus aureus, we investigated whether similar mutations were present in LZD(r) staphylococci of clinical origin. Sequence analysis of a variety of LZD(r) isolates revealed two L3 mutations, DeltaSer145 (S. aureus NRS127) and Ala157Arg (Staphylococcus epidermidis 1653059), both occurring proximal to the oxazolidinone binding site in the peptidyl transferase center. The oxazolidinone torezolid maintained a >or=8-fold potency advantage over linezolid for both strains.

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Year:  2009        PMID： 19805557      PMCID： PMC2786331          DOI： 10.1128/AAC.01032-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides.

Authors:  Anne-Laure Prunier; Brigitte Malbruny; Didier Tandé; Bertrand Picard; Roland Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

2.  Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.

Authors:  Klaudia Kosowska-Shick; Catherine Clark; Kim Credito; Pamela McGhee; Bonifacio Dewasse; Tatiana Bogdanovich; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

3.  Linezolid resistance in a clinical isolate of Staphylococcus aureus.

Authors:  S Tsiodras; H S Gold; G Sakoulas; G M Eliopoulos; C Wennersten; L Venkataraman; R C Moellering; M J Ferraro
Journal:  Lancet       Date:  2001-07-21       Impact factor: 79.321

4.  Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.

Authors:  J Prystowsky; F Siddiqui; J Chosay; D L Shinabarger; J Millichap; L R Peterson; G A Noskin
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

5.  A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

Authors:  Corinna Kehrenberg; Stefan Schwarz; Lene Jacobsen; Lykke H Hansen; Birte Vester
Journal:  Mol Microbiol       Date:  2005-08       Impact factor: 3.501

6.  In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides.

Authors:  H Carsenti-Dellamonica; M Galimand; F Vandenbos; C Pradier; P M Roger; B Dunais; M Sabah; G Mancini; P Dellamonica
Journal:  J Antimicrob Chemother       Date:  2005-08-31       Impact factor: 5.790

7.  Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations.

Authors:  P Sander; L Belova; Y G Kidan; P Pfister; A S Mankin; E C Böttger
Journal:  Mol Microbiol       Date:  2002-12       Impact factor: 3.501

8.  Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

Authors:  Märit Pringle; Jacob Poehlsgaard; Birte Vester; Katherine S Long
Journal:  Mol Microbiol       Date:  2004-12       Impact factor: 3.501

9.  Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.

Authors:  Satish K Pillai; George Sakoulas; Christine Wennersten; George M Eliopoulos; Robert C Moellering; Mary Jane Ferraro; Howard S Gold
Journal:  J Infect Dis       Date:  2002-11-04       Impact factor: 5.226

10.  Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

Authors:  Jeffrey B Locke; Mark Hilgers; Karen Joy Shaw
Journal:  Antimicrob Agents Chemother       Date:  2009-09-14       Impact factor: 5.191
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  51 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Clonal dissemination of linezolid-resistant Staphylococcus haemolyticus exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary care hospital in Brazil.

Authors:  Lara M de Almeida; Nilton Lincopan; Maria Rita E de Araújo; Elsa M Mamizuka
Journal:  Antimicrob Agents Chemother       Date:  2012-02-06       Impact factor: 5.191

3.  Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.

Authors:  Katherine S Long; Christian Munck; Theis M B Andersen; Maria A Schaub; Sven N Hobbie; Erik C Böttger; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

4.  First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization.

Authors:  Rodrigo E Mendes; Lalitagauri Deshpande; Eduardo Rodriguez-Noriega; James E Ross; Ronald N Jones; Rayo Morfin-Otero
Journal:  J Clin Microbiol       Date:  2010-06-02       Impact factor: 5.948

5.  Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.

Authors:  Jeffrey B Locke; Douglas E Zuill; Caitlyn R Scharn; Jennifer Deane; Daniel F Sahm; Gerald A Denys; Richard V Goering; Karen J Shaw
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

6.  Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.

Authors:  Carmen Betriu; Gracia Morales; Icíar Rodríguez-Avial; Esther Culebras; María Gómez; Fátima López-Fabal; Juan J Picazo
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

7.  Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unit.

Authors:  A Mazzariol; G Lo Cascio; E Kocsis; L Maccacaro; R Fontana; G Cornaglia
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-07-27       Impact factor: 3.267

8.  Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance.

Authors:  Jacqueline M LaMarre; Benjamin P Howden; Alexander S Mankin
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

9.  Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.

Authors:  Rasmus N Klitgaard; Eleni Ntokou; Katrine Nørgaard; Daniel Biltoft; Lykke H Hansen; Nicolai M Trædholm; Jacob Kongsted; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2015-04-06       Impact factor: 5.191

10.  Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.

Authors:  Wei Gao; Kyra Chua; John K Davies; Hayley J Newton; Torsten Seemann; Paul F Harrison; Natasha E Holmes; Hyun-Woo Rhee; Jong-In Hong; Elizabeth L Hartland; Timothy P Stinear; Benjamin P Howden
Journal:  PLoS Pathog       Date:  2010-06-10       Impact factor: 6.823
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