Literature DB >> 20577838

Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line.

Hua Zhong1, Hai-rong Wang, Shuang Yang, Ji-hua Zhong, Ting Wang, Chun Wang, Fang-yuan Chen.   

Abstract

The expression pattern of microRNAs (miRNAs) and their potential target genes were investigated in acute promyelocytic leukemia (APL) cell line NB4 cells during all-trans-retinoid acid (ATRA) treatment by using a miRNA microarrays platform and real-time quantitative PCR (RTQ-PCR). MiR-146a as one of the miRNAs down-regulated by ATRA during APL differentiation was identified. Direct interaction between miR146a and its predictive target gene Smad4 were confirmed by Luciferase assay. Down-regulation of miR-146a and upregulation of Smad4 at protein levels were demonstrated. These data suggested that miR-146a might influence proliferation of APL cells through TGF-beta1/Smad signal transduction pathway during ATRA induction.

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Year:  2010        PMID： 20577838     DOI： 10.1007/s12185-010-0626-5

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  23 in total

1.  Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis.

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Journal:  Oncogene       Date:  2001-01-04       Impact factor: 9.867

Review 2.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors:  Yigong Shi; Joan Massagué
Journal:  Cell       Date:  2003-06-13       Impact factor: 41.582

Review 3.  The role of microRNAs in normal hematopoiesis and hematopoietic malignancies.

Authors:  J Kluiver; B-J Kroesen; S Poppema; A van den Berg
Journal:  Leukemia       Date:  2006-09-14       Impact factor: 11.528

4.  A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.

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Journal:  Cell       Date:  2005-12-02       Impact factor: 41.582

Review 5.  Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.

Authors:  H-M Shih; C-C Chang; H-Y Kuo; D-Y Lin
Journal:  Biochem Soc Trans       Date:  2007-12       Impact factor: 5.407

6.  A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells.

Authors:  M L De Marchis; M Ballarino; B Salvatori; M C Puzzolo; I Bozzoni; A Fatica
Journal:  Leukemia       Date:  2009-01-08       Impact factor: 11.528

7.  Prediction of mammalian microRNA targets.

Authors:  Benjamin P Lewis; I-hung Shih; Matthew W Jones-Rhoades; David P Bartel; Christopher B Burge
Journal:  Cell       Date:  2003-12-26       Impact factor: 41.582

8.  MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.

Authors:  Ramiro Garzon; Stefano Volinia; Chang-Gong Liu; Cecilia Fernandez-Cymering; Tiziana Palumbo; Flavia Pichiorri; Muller Fabbri; Kevin Coombes; Hansjuerg Alder; Tatsuya Nakamura; Neal Flomenberg; Guido Marcucci; George A Calin; Steven M Kornblau; Hagop Kantarjian; Clara D Bloomfield; Michael Andreeff; Carlo M Croce
Journal:  Blood       Date:  2008-01-10       Impact factor: 22.113

9.  MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis.

Authors:  S Debernardi; S Skoulakis; G Molloy; T Chaplin; A Dixon-McIver; B D Young
Journal:  Leukemia       Date:  2007-03-01       Impact factor: 11.528

10.  Real-time quantification of microRNAs by stem-loop RT-PCR.

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Journal:  Nucleic Acids Res       Date:  2005-11-27       Impact factor: 16.971
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  31 in total

1.  Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation.

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Journal:  Med Oncol       Date:  2012-02-07       Impact factor: 3.064

2.  Differential miRNA profile on photoaged primary human fibroblasts irradiated with ultraviolet A.

Authors:  Wei Li; Bing-Rong Zhou; Li-Juan Hua; Ze Guo; Dan Luo
Journal:  Tumour Biol       Date:  2013-07-07

3.  Effect and mechanism of microRNA-10b on proliferation and invasion of esophageal cancer cells.

Authors:  Yi Liu; Adili Salai; Dan He; Shengli Gao; Wei Zeng
Journal:  Exp Ther Med       Date:  2019-08-26       Impact factor: 2.447

4.  Short Communication: Studying the Role of Smart Flare Gold Nano Particles in Studying Micro RNA and Oncogene Differential Expression in Prostate Cancer Cell Lines.

Authors:  Hirendra Banerjee; Jamel Joyner; Monet Stevenson; William Kaha; Christopher Krauss; Sasha Hodges; Eduardo Santos; Myla Worthington; Jeffferey Rousch; Gloria Payne; Vinod Manglik; Narendra Banerjee; Brianna Morris; Dayton Bell; Santosh Mandal
Journal:  J Can Res Updates       Date:  2017-06-14

Review 5.  MicroRNA-146a and hemopoietic disorders.

Authors:  Zhong Hua; Wang Chun; Chen Fang-Yuan
Journal:  Int J Hematol       Date:  2011-09-08       Impact factor: 2.490

6.  Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells.

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Journal:  Inflammation       Date:  2012-08       Impact factor: 4.092

Review 7.  MicroRNA and cancer chemoprevention.

Authors:  Bin Yi; Gary A Piazza; Xiulan Su; Yaguang Xi
Journal:  Cancer Prev Res (Phila)       Date:  2013-03-26

8.  Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study.

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Journal:  Tumour Biol       Date:  2014-04-17

Review 9.  Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.

Authors:  Qihe Xu; Jeffrey B Kopp
Journal:  Semin Nephrol       Date:  2012-05       Impact factor: 5.299

10.  Recurrent miscarriage and micro-RNA among north Indian women.

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Journal:  Reprod Sci       Date:  2014-04-03       Impact factor: 3.060
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