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Literature DB >> 12809600

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Abstract

TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus.

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Year: 2003 PMID： 12809600 DOI： 10.1016/s0092-8674(03)00432-x

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

2000 in total

1. Aberrant signaling pathways in pancreatic cancer: a two compartment view.

Authors: Angela L McCleary-Wheeler; Robert McWilliams; Martin E Fernandez-Zapico
Journal: Mol Carcinog Date: 2012-01 Impact factor: 4.784

2. Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration.

Authors: Wen-Pin Chen; Yuan-Hung Liu; Yi-Jin Ho; Sean M Wu
Journal: Cardiovasc Res Date: 2014-10-31 Impact factor: 10.787

3. The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.

Authors: Chenxi Tian; Debjeet Sen; Herong Shi; Marisa L Foehr; Yevgeniy Plavskin; Olena K Vatamaniuk; Jun Liu
Journal: Development Date: 2010-06-09 Impact factor: 6.868

4. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.

Authors: Mahta Nili; Ujwal Shinde; Peter Rotwein
Journal: J Biol Chem Date: 2010-06-08 Impact factor: 5.157

5. VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB₂ receptor-dependent pathways.

Authors: Carmen Del Rio; Irene Cantarero; Belén Palomares; María Gómez-Cañas; Javier Fernández-Ruiz; Carolina Pavicic; Adela García-Martín; Maria Luz Bellido; Rafaela Ortega-Castro; Carlos Pérez-Sánchez; Chary López-Pedrera; Giovanni Appendino; Marco A Calzado; Eduardo Muñoz
Journal: Br J Pharmacol Date: 2018-08-23 Impact factor: 8.739

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

1. Aberrant signaling pathways in pancreatic cancer: a two compartment view.

2. Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration.

3. The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.

4. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.

5. VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB₂ receptor-dependent pathways.

Review 6. The microRNA networks of TGFβ signaling in cancer.

7. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

Review 8. Role of SMAD proteins in colitis-associated cancer: from known to the unknown.

9. An early requirement for maternal FoxH1 during zebrafish gastrulation.

10. Uterine epithelial cell proliferation and endometrial hyperplasia: evidence from a mouse model.