Literature DB >> 20542429

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Yizhou Dong1, Kyoko Nakagawa-Goto, Chin-Yu Lai, Susan L Morris-Natschke, Kenneth F Bastow, Kuo-Hsiung Lee.   

Abstract

4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotoxic activity. Among all 4-substituted ABO analogs, cyclohexyl (12), N-methoxy-N-methylacetamide (14), and various aromatic derivatives (15-25 and 27) exhibited promising cell growth inhibitory activity with ED(50) values of 0.01-5.8 microM against all tested tumor cell lines. The 4'-methoxyphenyl derivative (18) and 3'-methylphenyl derivative (24) showed the most potent antitumor activity against a broad range of cancer cell lines with ED(50) values of 0.01-76 microM. Preliminary SAR results indicated that substitutions on nitrogen are critical to the antitumor potency. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20542429      PMCID： PMC2917187          DOI： 10.1016/j.bmcl.2010.05.079

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Natural products in the process of finding new drug candidates.

Authors:  P Vuorelaa; M Leinonenb; P Saikkuc; P Tammelaa; J-P Rauhad; T Wennberge; H Vuorela
Journal:  Curr Med Chem       Date:  2004-06       Impact factor: 4.530

2.  Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.

Authors:  Xihong Wang; Kyoko Nakagawa-Goto; Kenneth F Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2006-09-07       Impact factor: 7.446

Review 3.  Plant-derived compounds in clinical trials.

Authors:  Arvind Saklani; Samuel K Kutty
Journal:  Drug Discov Today       Date:  2007-11-26       Impact factor: 7.851

4.  Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.

Authors:  Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2009-06-11       Impact factor: 7.446

Review 5.  Natural products as a robust source of new drugs and drug leads: past successes and present day issues.

Authors:  Gilbert M Rishton
Journal:  Am J Cardiol       Date:  2008-05-22       Impact factor: 2.778

6.  Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

Authors:  Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Nakagawa-Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Arnold Brossi; Jing-Yu Lang; Jennifer L Hsu; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2010-03-11       Impact factor: 7.446

7.  Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

Authors:  Xihong Wang; Kenneth F Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2004-11-04       Impact factor: 7.446

8.  Pyran derivatives. Part XXI. Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones.

Authors:  Mario Di Braccio; Giancarlo Grossi; Giorgio Roma; Cristina Marzano; Franca Baccichetti; Morena Simonato; Franco Bordin
Journal:  Farmaco       Date:  2003-11

9.  Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Authors:  Yizhou Dong; Qian Shi; Kyoko Nakagawa-Goto; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2009-09-29       Impact factor: 2.823

10.  Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.

Authors:  Yizhou Dong; Qian Shi; Kyoko Nakagawa-Goto; Pei-Chi Wu; Susan L Morris-Natschke; Arnold Brossi; Kenneth F Bastow; Jing-Yu Lang; Mien-Chie Hung; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2009-12-02       Impact factor: 3.641
  10 in total
  5 in total

1.  Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Yoon Kim; Eva Y-H P Lee; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2012-02-03       Impact factor: 4.050

2.  Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-03-21       Impact factor: 2.823

3.  Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-11-17       Impact factor: 2.823

4.  Phytochemicals of Salacia oblonga responsible for free radical scavenging and antiproliferative activity against breast cancer cell lines (MDA-MB-231).

Authors:  Anjaneyulu Musini; Jayaram Prakash Rao; Archana Giri
Journal:  Physiol Mol Biol Plants       Date:  2015-09-04

Review 5.  Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

Authors:  Kuo-Hsiung Lee; Susan Morris-Natschke; Keduo Qian; Yizhou Dong; Xiaoming Yang; Ting Zhou; Eileen Belding; Shou-Fang Wu; Koji Wada; Toshiyuki Akiyama
Journal:  J Tradit Complement Med       Date:  2012-01
  5 in total

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