Literature DB >> 15509181

Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

Xihong Wang1, Kenneth F Bastow, Chang-Ming Sun, Yun-Lian Lin, Hsi-Jung Yu, Ming-Jaw Don, Tian-Shung Wu, Seikou Nakamura, Kuo-Hsiung Lee.   

Abstract

Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.

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Year:  2004        PMID： 15509181     DOI： 10.1021/jm040112r

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  29 in total

1.  Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Yoon Kim; Eva Y-H P Lee; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2012-02-03       Impact factor: 4.050

2.  Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-03-21       Impact factor: 2.823

3.  Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.

Authors:  Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2009-06-11       Impact factor: 7.446

Review 4.  Plant-derived natural product research aimed at new drug discovery.

Authors:  Hideji Itokawa; Susan L Morris-Natschke; Toshiyuki Akiyama; Kuo-Hsiung Lee
Journal:  J Nat Med       Date:  2008-04-22       Impact factor: 2.343

Review 5.  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Authors:  Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

6.  New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.

Authors:  M Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu
Journal:  Bioorg Med Chem       Date:  2011-03-04       Impact factor: 3.641

7.  In vitro cytotoxic potential of newly synthesized furo[3,2-c]pyran-4-one derivatives in cultured human lymphocytes.

Authors:  Halil Erhan Eroğlu; Irfan Koca; Ismail Yıldırım
Journal:  Cytotechnology       Date:  2011-05-15       Impact factor: 2.058

Review 8.  Phytotherapy and Nutritional Supplements on Breast Cancer.

Authors:  C M Lopes; A Dourado; R Oliveira
Journal:  Biomed Res Int       Date:  2017-08-06       Impact factor: 3.411

9.  Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

Authors:  Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Nakagawa-Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Arnold Brossi; Jing-Yu Lang; Jennifer L Hsu; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2010-03-11       Impact factor: 7.446

10.  Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-05-24       Impact factor: 2.823
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