Literature DB >> 19819136

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Yizhou Dong1, Qian Shi, Kyoko Nakagawa-Goto, Pei-Chi Wu, Kenneth F Bastow, Susan L Morris-Natschke, Kuo-Hsiung Lee.   

Abstract

Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO derivatives were found to be a promising novel class of in vitro antitumor agents. The cyclohexene ring-A could dramatically affect the antitumor activity and selectivity. Compound 20 showed the highest potency with ED(50) values of 0.7 and 1.7 microM against SK-BR-3 and ZR-75-1 breast cancer cell lines, respectively.

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Year:  2009        PMID： 19819136      PMCID： PMC2782515          DOI： 10.1016/j.bmcl.2009.09.092

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3.

Authors:  H J Sung; S M Choi; Y Yoon; K S An
Journal:  Exp Mol Med       Date:  1999-12-31       Impact factor: 8.718

2.  Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.

Authors:  Xihong Wang; Kyoko Nakagawa-Goto; Kenneth F Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2006-09-07       Impact factor: 7.446

3.  Chemistry. The renaissance of natural products as drug candidates.

Authors:  Ian Paterson; Edward A Anderson
Journal:  Science       Date:  2005-10-21       Impact factor: 47.728

4.  Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.

Authors:  Christian Fischer; Gregory C Fu
Journal:  J Am Chem Soc       Date:  2005-04-06       Impact factor: 15.419

Review 5.  Biodiversity as a source of anticancer drugs.

Authors:  G Tan; C Gyllenhaal; D D Soejarto
Journal:  Curr Drug Targets       Date:  2006-03       Impact factor: 3.465

Review 6.  Plant-derived compounds in clinical trials.

Authors:  Arvind Saklani; Samuel K Kutty
Journal:  Drug Discov Today       Date:  2007-11-26       Impact factor: 7.851

Review 7.  Global cancer statistics in the year 2000.

Authors:  D M Parkin
Journal:  Lancet Oncol       Date:  2001-09       Impact factor: 41.316

Review 8.  New developments in the chemistry and biology of the bioactive constituents of Tanshen.

Authors:  Xihong Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2007-01       Impact factor: 12.944

9.  Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

Authors:  Xihong Wang; Kenneth F Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2004-11-04       Impact factor: 7.446

10.  Anticancer effects of tanshinone I in human non-small cell lung cancer.

Authors:  Chen-Yu Lee; Hui-Fang Sher; Huei-Wen Chen; Chun-Chi Liu; Ching-Hsien Chen; Choun-Sea Lin; Pan-Chyr Yang; Hsin-Sheng Tsay; Jeremy J W Chen
Journal:  Mol Cancer Ther       Date:  2008-11       Impact factor: 6.261
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  9 in total

1.  Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-03-21       Impact factor: 2.823

2.  Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-05-24       Impact factor: 2.823

3.  Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Yoon Kim; Susan L Morris-Natschke; Eva Y-H P Lee; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-11-21       Impact factor: 2.823

4.  Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-11-17       Impact factor: 2.823

Review 5.  Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

Authors:  Kuo-Hsiung Lee; Susan Morris-Natschke; Keduo Qian; Yizhou Dong; Xiaoming Yang; Ting Zhou; Eileen Belding; Shou-Fang Wu; Koji Wada; Toshiyuki Akiyama
Journal:  J Tradit Complement Med       Date:  2012-01

6.  New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation.

Authors:  Gülhan Turan-Zitouni; Leyla Yurttaş; Aouatef Tabbi; Gülşen Akalın Çiftçi; Halide Edip Temel; Zafer Asım Kaplancıklı
Journal:  Molecules       Date:  2018-01-10       Impact factor: 4.411

7.  Synthesis, molecular docking and preliminary in-vitro cytotoxic evaluation of some substituted tetrahydro-naphthalene (2',3',4',6'-tetra-O-acetyl-β-D-gluco/-galactopyranosyl) derivatives.

Authors:  Maha S Al-Mutairi; Ebtehal S Al-Abdullah; Mogedda E Haiba; Mohammed A Khedr; Wafaa A Zaghary
Journal:  Molecules       Date:  2012-04-23       Impact factor: 4.411

8.  Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives.

Authors:  Ebtehal S Al-Abdullah
Journal:  Molecules       Date:  2011-04-20       Impact factor: 4.411

Review 9.  Furo[3,2-c]coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanisms.

Authors:  Iván Cortés; L Javier Cala; Andrea B J Bracca; Teodoro S Kaufman
Journal:  RSC Adv       Date:  2020-09-10       Impact factor: 4.036
  9 in total

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