Literature DB >> 20034799

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.

Yizhou Dong1, Qian Shi, Kyoko Nakagawa-Goto, Pei-Chi Wu, Susan L Morris-Natschke, Arnold Brossi, Kenneth F Bastow, Jing-Yu Lang, Mien-Chie Hung, Kuo-Hsiung Lee.   

Abstract

6-Phenyl-4H-furo[3,2-c]pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10-13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100-250-fold more potent against SK-BR-3 (ED(50) 0.28 and 0.44microM, respectively) compared with other cancer cell lines tested. In addition, 25 displayed low cytotoxicity against normal breast cell lines 184A1 and MCF10A. Compounds 25 and 27 merit further investigation in our continuing program to generate and develop selective anti-breast cancer agents. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20034799      PMCID： PMC2821697          DOI： 10.1016/j.bmc.2009.11.049

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  15 in total

1.  Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.

Authors:  Xihong Wang; Kyoko Nakagawa-Goto; Kenneth F Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2006-09-07       Impact factor: 7.446

Review 2.  Drug discovery from medicinal plants.

Authors:  Marcy J Balunas; A Douglas Kinghorn
Journal:  Life Sci       Date:  2005-09-29       Impact factor: 5.037

Review 3.  Plant-derived compounds in clinical trials.

Authors:  Arvind Saklani; Samuel K Kutty
Journal:  Drug Discov Today       Date:  2007-11-26       Impact factor: 7.851

4.  Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.

Authors:  Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2009-06-11       Impact factor: 7.446

5.  Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

Authors:  Xihong Wang; Kenneth F Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2004-11-04       Impact factor: 7.446

6.  New heterocyclic precursors for thermal generation of reactive, electron-rich 1,2-diaza-1,3-butadienes.

Authors:  R K Boeckman; P Ge; J E Reed
Journal:  Org Lett       Date:  2001-11-15       Impact factor: 6.005

Review 7.  Targeted cancer therapy: conferring specificity to cytotoxic drugs.

Authors:  Ravi V J Chari
Journal:  Acc Chem Res       Date:  2007-08-18       Impact factor: 22.384

8.  Cytotoxic simplified tubulysin analogues.

Authors:  Bhooma Raghavan; Ranganathan Balasubramanian; Jaeson C Steele; Dan L Sackett; Robert A Fecik
Journal:  J Med Chem       Date:  2008-03-04       Impact factor: 7.446

9.  Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502).

Authors:  Humcha K Hariprakasha; Teresa Kosakowska-Cholody; Colin Meyer; Wieslaw M Cholody; Sherman F Stinson; Nadya I Tarasova; Christopher J Michejda
Journal:  J Med Chem       Date:  2007-10-16       Impact factor: 7.446

Review 10.  Early breast cancer in the elderly: assessment and management considerations.

Authors:  Gilles Albrand; Catherine Terret
Journal:  Drugs Aging       Date:  2008       Impact factor: 4.271
View more
  5 in total

1.  Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-03-21       Impact factor: 2.823

2.  In vitro cytotoxic potential of newly synthesized furo[3,2-c]pyran-4-one derivatives in cultured human lymphocytes.

Authors:  Halil Erhan Eroğlu; Irfan Koca; Ismail Yıldırım
Journal:  Cytotechnology       Date:  2011-05-15       Impact factor: 2.058

3.  Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-05-24       Impact factor: 2.823

4.  Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.

Authors:  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2010-11-17       Impact factor: 2.823

Review 5.  Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

Authors:  Kuo-Hsiung Lee; Susan Morris-Natschke; Keduo Qian; Yizhou Dong; Xiaoming Yang; Ting Zhou; Eileen Belding; Shou-Fang Wu; Koji Wada; Toshiyuki Akiyama
Journal:  J Tradit Complement Med       Date:  2012-01
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.