Literature DB >> 20510918

Quantitative genetic interactions reveal biological modularity.

Pedro Beltrao1, Gerard Cagney, Nevan J Krogan.   

Abstract

Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20510918      PMCID： PMC2946632          DOI： 10.1016/j.cell.2010.05.019

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  67 in total

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