Literature DB >> 20493671

Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.

Lara G Chepenik1, Mariella Raffo, Michelle Hampson, Cheryl Lacadie, Fei Wang, Monique M Jones, Brian Pittman, Pawel Skudlarski, Hilary P Blumberg.   

Abstract

Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.

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Year:  2010        PMID: 20493671      PMCID: PMC2914819          DOI: 10.1016/j.pscychresns.2010.04.002

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  48 in total

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