| Literature DB >> 20493671 |
Lara G Chepenik1, Mariella Raffo, Michelle Hampson, Cheryl Lacadie, Fei Wang, Monique M Jones, Brian Pittman, Pawel Skudlarski, Hilary P Blumberg.
Abstract
Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.Entities:
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Year: 2010 PMID: 20493671 PMCID: PMC2914819 DOI: 10.1016/j.pscychresns.2010.04.002
Source DB: PubMed Journal: Psychiatry Res ISSN: 0165-1781 Impact factor: 3.222