OBJECTIVE: This study sought to investigate neural activity in the amygdala during episodes of mania. METHOD: Nine manic subjects and nine healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while performing a neuropsychological paradigm known to activate the amygdala. Subjects viewed faces displaying affect (experimental task) and geometric forms (control task) and matched them to one of two simultaneously presented similar images. RESULTS: Manic subjects had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbitofrontal cortex relative to the comparison subjects. CONCLUSIONS: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.
OBJECTIVE: This study sought to investigate neural activity in the amygdala during episodes of mania. METHOD: Nine manic subjects and nine healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while performing a neuropsychological paradigm known to activate the amygdala. Subjects viewed faces displaying affect (experimental task) and geometric forms (control task) and matched them to one of two simultaneously presented similar images. RESULTS:Manic subjects had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbitofrontal cortex relative to the comparison subjects. CONCLUSIONS: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.
Authors: Nathalie Vizueta; Jeffrey D Rudie; Jennifer D Townsend; Salvatore Torrisi; Teena D Moody; Susan Y Bookheimer; Lori L Altshuler Journal: Am J Psychiatry Date: 2012-08 Impact factor: 18.112
Authors: M T Keener; J C Fournier; B C Mullin; D Kronhaus; S B Perlman; E LaBarbara; J C Almeida; M L Phillips Journal: Psychol Med Date: 2012-01-25 Impact factor: 7.723
Authors: Lara C Foland-Ross; Paul M Thompson; Catherine A Sugar; Sarah K Madsen; Jim K Shen; Conor Penfold; Kyle Ahlf; Paul E Rasser; Jeffrey Fischer; Yilan Yang; Jennifer Townsend; Susan Y Bookheimer; Lori L Altshuler Journal: Am J Psychiatry Date: 2011-02-01 Impact factor: 18.112
Authors: Birgit Abler; Ian Greenhouse; Dost Ongur; Henrik Walter; Stephan Heckers Journal: Neuropsychopharmacology Date: 2007-11-07 Impact factor: 7.853
Authors: Amy S Garrett; Allan L Reiss; Meghan E Howe; Ryan G Kelley; Manpreet K Singh; Nancy E Adleman; Asya Karchemskiy; Kiki D Chang Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-06-27 Impact factor: 8.829