Cheng Yang1, Lei Li1, Xinyu Hu1, Qiang Luo1, Weihong Kuang1, Su Lui1, Xiaoqi Huang1, Jing Dai1, Manxi He1, Graham J. Kemp1, John A Sweeney1, Qiyong Gong1. 1. From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, China (Yang, Li, Hu, Luo, Lui, Huang, Sweeney, Gong); the Department of Psychiatry, West China Hospital of Sichuan University, China (Kuang); the Department of Psychoradiology, Chengdu Mental Health Center, China (Kuang, Dai, He); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom (Kemp); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); and the Department of Psychology, School of Public Administration, Sichuan University, China (Gong).
Abstract
Background: An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder. Methods: We conducted a systematic search up to May 2017 for all TBSS studies comparing fractional anisotropy (FA) between patients with bipolar disorder and healthy controls. We performed anisotropic effect size–signed differential mapping meta-analysis. Results: We identified a total of 22 data sets including 556 patients with bipolar disorder and 623 healthy controls. We found significant FA reductions in the genu and body of the corpus callosum in patients with bipolar disorder relative to healthy controls. No regions of increased FA were reported. In subgroup analyses, the FA reduction in the genu of the corpus callosum retained significance in patients with bipolar disorder type I, and the FA reduction in the body of the corpus callosum retained significance in euthymic patients with bipolar disorder. Meta-regression analysis revealed that the percentage of female patients was negatively correlated with reduced FA in the body of the corpus callosum. Limitations: Data acquisition, patient characteristics and clinical variables in the included studies were heterogeneous. The small number of diffusion tensor imaging studies using TBSS in patients with bipolar disorder type II, as well as the lack of other clinical information, hindered the application of subgroup meta-analyses. Conclusion: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder.
Background: An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder. Methods: We conducted a systematic search up to May 2017 for all TBSS studies comparing fractional anisotropy (FA) between patients with bipolar disorder and healthy controls. We performed anisotropic effect size–signed differential mapping meta-analysis. Results: We identified a total of 22 data sets including 556 patients with bipolar disorder and 623 healthy controls. We found significant FA reductions in the genu and body of the corpus callosum in patients with bipolar disorder relative to healthy controls. No regions of increased FA were reported. In subgroup analyses, the FA reduction in the genu of the corpus callosum retained significance in patients with bipolar disorder type I, and the FA reduction in the body of the corpus callosum retained significance in euthymic patients with bipolar disorder. Meta-regression analysis revealed that the percentage of female patients was negatively correlated with reduced FA in the body of the corpus callosum. Limitations: Data acquisition, patient characteristics and clinical variables in the included studies were heterogeneous. The small number of diffusion tensor imaging studies using TBSS in patients with bipolar disorder type II, as well as the lack of other clinical information, hindered the application of subgroup meta-analyses. Conclusion: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder.
Authors: Adrian J Lloyd; Heba E Ali; David Nesbitt; P Brian Moore; Allan H Young; I Nicol Ferrier Journal: Br J Psychiatry Date: 2013-12-19 Impact factor: 9.319
Authors: Franz-Xaver Neubert; Rogier B Mars; Jérôme Sallet; Matthew F S Rushworth Journal: Proc Natl Acad Sci U S A Date: 2015-05-06 Impact factor: 11.205
Authors: Pauline Favre; Melissa Pauling; Jacques Stout; Franz Hozer; Samuel Sarrazin; Christoph Abé; Martin Alda; Clara Alloza; Silvia Alonso-Lana; Ole A Andreassen; Bernhard T Baune; Francesco Benedetti; Geraldo F Busatto; Erick J Canales-Rodríguez; Xavier Caseras; Tiffany Moukbel Chaim-Avancini; Christopher R K Ching; Udo Dannlowski; Michael Deppe; Lisa T Eyler; Mar Fatjo-Vilas; Sonya F Foley; Dominik Grotegerd; Tomas Hajek; Unn K Haukvik; Fleur M Howells; Neda Jahanshad; Harald Kugel; Trine V Lagerberg; Stephen M Lawrie; Julia O Linke; Andrew McIntosh; Elisa M T Melloni; Philip B Mitchell; Mircea Polosan; Edith Pomarol-Clotet; Jonathan Repple; Gloria Roberts; Annerine Roos; Pedro G P Rosa; Raymond Salvador; Salvador Sarró; Peter R Schofield; Mauricio H Serpa; Kang Sim; Dan J Stein; Jess E Sussmann; Henk S Temmingh; Paul M Thompson; Norma Verdolini; Eduard Vieta; Michele Wessa; Heather C Whalley; Marcus V Zanetti; Marion Leboyer; Jean-François Mangin; Chantal Henry; Edouard Duchesnay; Josselin Houenou Journal: Neuropsychopharmacology Date: 2019-08-21 Impact factor: 7.853
Authors: Anna Manelis; Adriane Soehner; Yaroslav O Halchenko; Skye Satz; Rachel Ragozzino; Mora Lucero; Holly A Swartz; Mary L Phillips; Amelia Versace Journal: Sci Rep Date: 2021-04-06 Impact factor: 4.996
Authors: Julia O Linke; Caitlin Stavish; Nancy E Adleman; Joelle Sarlls; Kenneth E Towbin; Ellen Leibenluft; Melissa A Brotman Journal: Bipolar Disord Date: 2020-01-21 Impact factor: 6.744