Literature DB >> 20464029

Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.

Yun Xie1, Andrew V Dix, Yitzhak Tor.   

Abstract

A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic.

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Year:  2010        PMID： 20464029      PMCID： PMC3035430          DOI： 10.1039/c0cc00423e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  32 in total

1.  Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics.

Authors:  A P Carter; W M Clemons; D E Brodersen; R J Morgan-Warren; B T Wimberly; V Ramakrishnan
Journal:  Nature       Date:  2000-09-21       Impact factor: 49.962

Review 2.  A-site model RNAs.

Authors:  T Hermann
Journal:  Biochimie       Date:  2006-07-14       Impact factor: 4.079

Review 3.  The ribosomal A-site as an inspiration for the design of RNA binders.

Authors:  Y Tor
Journal:  Biochimie       Date:  2006-03-27       Impact factor: 4.079

4.  Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization.

Authors:  Seergazhi G Srivatsan; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2007-01-26       Impact factor: 15.419

5.  Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.

Authors:  Susan J Schroeder; Gregor Blaha; Peter B Moore
Journal:  Antimicrob Agents Chemother       Date:  2007-07-30       Impact factor: 5.191

Review 6.  The use of ribosomal crystal structures in antibiotic drug design.

Authors:  Brian T Wimberly
Journal:  Curr Opin Investig Drugs       Date:  2009-08

7.  Structural origins of aminoglycoside specificity for prokaryotic ribosomes.

Authors:  S R Lynch; J D Puglisi
Journal:  J Mol Biol       Date:  2001-03-09       Impact factor: 5.469

8.  FRET enabled real time detection of RNA-small molecule binding.

Authors:  Yun Xie; Andrew V Dix; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

9.  Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.

Authors:  Sven N Hobbie; Subramanian Akshay; Sarath K Kalapala; Christian M Bruell; Dmitry Shcherbakov; Erik C Böttger
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-22       Impact factor: 11.205

10.  Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria.

Authors:  Sven N Hobbie; Sarath K Kalapala; Subramanian Akshay; Christian Bruell; Sebastian Schmidt; Sabine Dabow; Andrea Vasella; Peter Sander; Erik C Böttger
Journal:  Nucleic Acids Res       Date:  2007-08-30       Impact factor: 16.971
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  10 in total

1.  Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Authors:  Nelson B Olivier; Roger B Altman; Jonas Noeske; Gregory S Basarab; Erin Code; Andrew D Ferguson; Ning Gao; Jian Huang; Manuel F Juette; Stephania Livchak; Matthew D Miller; D Bryan Prince; Jamie H D Cate; Ed T Buurman; Scott C Blanchard
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

2.  Design, synthesis, and spectroscopic properties of extended and fused pyrrolo-dC and pyrrolo-C analogs.

Authors:  Mary S Noé; Andro C Ríos; Yitzhak Tor
Journal:  Org Lett       Date:  2012-05-30       Impact factor: 6.005

3.  Emissive RNA alphabet.

Authors:  Dongwon Shin; Renatus W Sinkeldam; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2011-09-02       Impact factor: 15.419

4.  Selectively guanidinylated aminoglycosides as antibiotics.

Authors:  Richard J Fair; Mary E Hensler; Wdee Thienphrapa; Quang N Dam; Victor Nizet; Yitzhak Tor
Journal:  ChemMedChem       Date:  2012-05-25       Impact factor: 3.466

5.  Fluorescent ribonucleoside as a FRET acceptor for tryptophan in native proteins.

Authors:  Yun Xie; Tucker Maxson; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2010-09-01       Impact factor: 15.419

6.  Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.

Authors:  Renatus W Sinkeldam; Lisa S McCoy; Dongwon Shin; Yitzhak Tor
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-29       Impact factor: 15.336

7.  Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria.

Authors:  Richard J Fair; Lisa S McCoy; Mary E Hensler; Bernice Aguilar; Victor Nizet; Yitzhak Tor
Journal:  ChemMedChem       Date:  2014-07-23       Impact factor: 3.466

8.  Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

Authors:  Lisa S McCoy; Kade D Roberts; Roger L Nation; Philip E Thompson; Tony Velkov; Jian Li; Yitzhak Tor
Journal:  Chembiochem       Date:  2013-09-18       Impact factor: 3.164

9.  Direct observation of aminoglycoside-RNA binding by localized surface plasmon resonance spectroscopy.

Authors:  Ludmila Frolov; Andrew Dix; Yitzhak Tor; Alexander B Tesler; Yulia Chaikin; Alexander Vaskevich; Israel Rubinstein
Journal:  Anal Chem       Date:  2013-01-31       Impact factor: 6.986

10.  A boost for the emerging field of RNA nanotechnology.

Authors:  Girish C Shukla; Farzin Haque; Yitzhak Tor; L Marcus Wilhelmsson; Jean-Jacques Toulmé; Hervé Isambert; Peixuan Guo; John J Rossi; Scott A Tenenbaum; Bruce A Shapiro
Journal:  ACS Nano       Date:  2011-05-24       Impact factor: 15.881
  10 in total

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