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Literature DB >> 24105917

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

Lisa S McCoy¹, Kade D Roberts, Roger L Nation, Philip E Thompson, Tony Velkov, Jian Li, Yitzhak Tor.

Abstract

Looking for targets: while the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A-sites, domains responsible for translational decoding. Polymyxin B, colistin and analogues also hinder eukaryotic translation in vitro. These new targets and effects might be partially responsible for the plethora of adverse effects by these potent bactericidal agents.

Entities: Chemical Disease Gene Species

Keywords: RNA; antibiotics; colistin; polymyxins; translation

Mesh：

Substances：

Year: 2013 PMID： 24105917 PMCID： PMC3947458 DOI： 10.1002/cbic.201300496

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

43 in total

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Review 3. Molecular basis of bacterial outer membrane permeability revisited.

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Authors: Christine Brotschi; Christian J Leumann
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5. Cationic peptide antimicrobials induce selective transcription of micF and osmY in Escherichia coli.

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Journal: Biochim Biophys Acta Date: 2000-01-15

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Journal: J Antimicrob Chemother Date: 1981-12 Impact factor: 5.790

13 in total

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5. Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria.

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Review 6. The yin and yang of bacterial resilience in the human gut microbiota.

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7. Purification of Bioactive Lipopeptides Produced by Bacillus subtilis Strain BIA.

Authors: Muaaz Alajlani; Abid Shiekh; Shahida Hasnain; Adelheid Brantner
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8. Polymyxins Facilitate Entry into Mammalian Cells.

Authors: Kristina M Hamill; Lisa S McCoy; Ezequiel Wexselblatt; Jeffrey D Esko; Yitzhak Tor
Journal: Chem Sci Date: 2016-04-25 Impact factor: 9.825

9. Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane.

Authors: Akshay Sabnis; Katheryn Lh Hagart; Anna Klöckner; Michele Becce; Lindsay E Evans; R Christopher D Furniss; Despoina Ai Mavridou; Ronan Murphy; Molly M Stevens; Jane C Davies; Gérald J Larrouy-Maumus; Thomas B Clarke; Andrew M Edwards
Journal: Elife Date: 2021-04-06 Impact factor: 8.140

10. Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells.

Authors: Mohammad A K Azad; Jian Li; Maizbha U Ahmed; Mengyao Li; Darren J Creek; Meiling Han; Fanfan Zhou; Kim Chan; Qi Tony Zhou; Tony Velkov
Journal: Antimicrob Agents Chemother Date: 2021-08-17 Impact factor: 5.191