Literature DB >> 17664317

Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.

Susan J Schroeder1, Gregor Blaha, Peter B Moore.   

Abstract

Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive.

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Year:  2007        PMID： 17664317      PMCID： PMC2167971          DOI： 10.1128/AAC.00455-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

Authors:  I S Gabashvili; S T Gregory; M Valle; R Grassucci; M Worbs; M C Wahl; A E Dahlberg; J Frank
Journal:  Mol Cell       Date:  2001-07       Impact factor: 17.970

2.  The structural basis of ribosome activity in peptide bond synthesis.

Authors:  P Nissen; J Hansen; N Ban; P B Moore; T A Steitz
Journal:  Science       Date:  2000-08-11       Impact factor: 47.728

3.  Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements.

Authors:  Kakoli Mitra; Christiane Schaffitzel; Felcy Fabiola; Michael S Chapman; Nenad Ban; Joachim Frank
Journal:  Mol Cell       Date:  2006-05-19       Impact factor: 17.970

4.  The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole.

Authors:  Susan J Schroeder; Gregor Blaha; Julian Tirado-Rives; Thomas A Steitz; Peter B Moore
Journal:  J Mol Biol       Date:  2007-02-07       Impact factor: 5.469

5.  Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.

Authors:  Masayuki Arakawa; Masataka Shiozuka; Yuki Nakayama; Takahiko Hara; Masa Hamada; Shin'ichi Kondo; Daishiro Ikeda; Yoshikazu Takahashi; Ryuichi Sawa; Yoshiaki Nonomura; Kianoush Sheykholeslami; Kenji Kondo; Kimitaka Kaga; Toshio Kitamura; Yuko Suzuki-Miyagoe; Shin'ichi Takeda; Ryoichi Matsuda
Journal:  J Biochem       Date:  2003-11       Impact factor: 3.387

6.  Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit.

Authors:  Jeffrey L Hansen; Peter B Moore; Thomas A Steitz
Journal:  J Mol Biol       Date:  2003-07-25       Impact factor: 5.469

7.  Conformationally restricted analogs of deoxynegamycin.

Authors:  B Raju; Sampathkumar Anandan; Shihai Gu; Prudencio Herradura; Hardwin O'Dowd; Bum Kim; Marcela Gomez; Corinne Hackbarth; Charlotte Wu; Wen Wang; Zhengyu Yuan; Richard White; Joaquim Trias; Dinesh V Patel
Journal:  Bioorg Med Chem Lett       Date:  2004-06-21       Impact factor: 2.823

8.  The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit.

Authors:  D J Klein; P B Moore; T A Steitz
Journal:  J Mol Biol       Date:  2004-06-25       Impact factor: 5.469

9.  N- and C-terminal modifications of negamycin.

Authors:  B Raju; Kathleen Mortell; Sampathkumar Anandan; Hardwin O'Dowd; Hongwu Gao; Marcela Gomez; Corinne Hackbarth; Charlotte Wu; Wen Wang; Zhengyu Yuan; Richard White; Joaquim Trias; Dinesh V Patel
Journal:  Bioorg Med Chem Lett       Date:  2003-07-21       Impact factor: 2.823

10.  The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs.

Authors:  Jamie J Cannone; Sankar Subramanian; Murray N Schnare; James R Collett; Lisa M D'Souza; Yushi Du; Brian Feng; Nan Lin; Lakshmi V Madabusi; Kirsten M Müller; Nupur Pande; Zhidi Shang; Nan Yu; Robin R Gutell
Journal:  BMC Bioinformatics       Date:  2002-01-17       Impact factor: 3.169
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  14 in total

1.  Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Authors:  Nelson B Olivier; Roger B Altman; Jonas Noeske; Gregory S Basarab; Erin Code; Andrew D Ferguson; Ning Gao; Jian Huang; Manuel F Juette; Stephania Livchak; Matthew D Miller; D Bryan Prince; Jamie H D Cate; Ed T Buurman; Scott C Blanchard
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

2.  When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

Authors:  Moran Shalev; Timor Baasov
Journal:  Medchemcomm       Date:  2014-08-01       Impact factor: 3.597

3.  Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.

Authors:  Yun Xie; Andrew V Dix; Yitzhak Tor
Journal:  Chem Commun (Camb)       Date:  2010-05-13       Impact factor: 6.222

Review 4.  Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.

Authors:  Kim M Keeling; David M Bedwell
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-07-06       Impact factor: 9.957

Review 5.  Nonsense suppression therapies in human genetic diseases.

Authors:  Patrícia Martins-Dias; Luísa Romão
Journal:  Cell Mol Life Sci       Date:  2021-03-22       Impact factor: 9.261

6.  Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.

Authors:  Güliz Gürel; Gregor Blaha; Thomas A Steitz; Peter B Moore
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

7.  U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.

Authors:  Güliz Gürel; Gregor Blaha; Peter B Moore; Thomas A Steitz
Journal:  J Mol Biol       Date:  2009-04-09       Impact factor: 5.469

8.  Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells.

Authors:  Célia Floquet; Jean-Pierre Rousset; Laure Bidou
Journal:  PLoS One       Date:  2011-08-31       Impact factor: 3.240

9.  Repurposing tRNAs for nonsense suppression.

Authors:  Suki Albers; Bertrand Beckert; Marco C Matthies; Chandra Sekhar Mandava; Raphael Schuster; Carolin Seuring; Maria Riedner; Suparna Sanyal; Andrew E Torda; Daniel N Wilson; Zoya Ignatova
Journal:  Nat Commun       Date:  2021-06-22       Impact factor: 14.919

10.  Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Authors:  Yury S Polikanov; Teresa Szal; Fuyan Jiang; Pulkit Gupta; Ryoichi Matsuda; Masataka Shiozuka; Thomas A Steitz; Nora Vázquez-Laslop; Alexander S Mankin
Journal:  Mol Cell       Date:  2014-10-09       Impact factor: 17.970
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