Literature DB >> 20407923

One-pot multicomponent synthesis of two novel thiolactone scaffolds.

B Beck1, S Srivastava, K Khoury, E Herdtweck, Alexander Dömling.   

Abstract

We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.

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Year:  2010        PMID： 20407923     DOI： 10.1007/s11030-010-9249-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  19 in total

1.  Ugi reaction in aqueous solutions: a simple protocol for libraries production.

Authors:  Maxim A Mironov; Maria N Ivantsova; Vladimir S Mokrushin
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.

Authors:  Il Whea Ku; Sangwon Cho; Munikumar Reddy Doddareddy; Min Seok Jang; Gyochang Keum; Jung-Ha Lee; Bong Young Chung; Youseung Kim; Hyewhon Rhim; Soon Bang Kang
Journal:  Bioorg Med Chem Lett       Date:  2006-07-28       Impact factor: 2.823

3.  Radiation protection by alpha-methyl-homocysteine thiolactone in vitro.

Authors:  K E Koch; J C Roberts; G Lubec
Journal:  Life Sci       Date:  1997       Impact factor: 5.037

4.  An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction.

Authors:  Y B Kim; E H Choi; G Keum; S B Kang; D H Lee; H Y Koh; Y Kim
Journal:  Org Lett       Date:  2001-12-27       Impact factor: 6.005

5.  A novel multicomponent synthesis of polysubstituted 5-aminooxazole and its new scaffold-generating reaction to pyrrolo[3,4-b]pyridine.

Authors:  X Sun; P Janvier; G Zhao; H Bienaymé; J Zhu
Journal:  Org Lett       Date:  2001-03-22       Impact factor: 6.005

6.  The disposition of prasugrel, a novel thienopyridine, in humans.

Authors:  Nagy A Farid; Richard L Smith; Todd A Gillespie; T James Rash; Patrick E Blair; Atsushi Kurihara; Mark J Goldberg
Journal:  Drug Metab Dispos       Date:  2007-04-02       Impact factor: 3.922

7.  Ammonium chloride-promoted four-component synthesis of pyrrolo[3,4-b]pyridin-5-one.

Authors:  Pierre Janvier; Xiaowen Sun; Hugues Bienaymé; Jieping Zhu
Journal:  J Am Chem Soc       Date:  2002-03-20       Impact factor: 15.419

8.  Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: a controlled study in current smokers with mild COPD.

Authors:  R W Dal Negro; M Visconti; C Micheletto; S Tognella
Journal:  Pulm Pharmacol Ther       Date:  2007-08-14       Impact factor: 3.410

9.  Application of MCR: facile one-pot diastereoselective syntheses of novel chiral alpha,alpha'-iminodiacetic acid analogues.

Authors:  Kuangsen Sung; Fu-Lin Chen; Meng-Jung Chung
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

10.  Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

Authors:  Siri Ram Chhabra; Chris Harty; Doreen S W Hooi; Mavis Daykin; Paul Williams; Gary Telford; David I Pritchard; Barrie W Bycroft
Journal:  J Med Chem       Date:  2003-01-02       Impact factor: 7.446
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  2 in total

1.  Expanding the substrate scope of Ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids.

Authors:  Maciej Dawidowski; Sławomir Sobczak; Marcin Wilczek; Artur Kulesza; Jadwiga Turło
Journal:  Mol Divers       Date:  2013-10-24       Impact factor: 2.943

2.  Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

Authors:  Kareem Khoury; Mantosh K Sinha; Tadamichi Nagashima; Eberhardt Herdtweck; Alexander Dömling
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-11       Impact factor: 15.336
  2 in total

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