Literature DB >> 15068081

Ugi reaction in aqueous solutions: a simple protocol for libraries production.

Maxim A Mironov1, Maria N Ivantsova, Vladimir S Mokrushin.   

Abstract

A reaction between levulinic acid, isocyanides and primary amines has been examined in distilled water and in surfactants solutions. It is demonstrated that the reaction gives good results at the different concentrations including one well above the solubility limit. A simple and eco-friendly protocol for libraries production is described.

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Year:  2003        PMID： 15068081     DOI： 10.1023/b:modi.0000006758.61294.57

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  4 in total

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Journal:  Comb Chem High Throughput Screen       Date:  2001-02       Impact factor: 1.339

2.  Dynamic combinatorial chemistry.

Authors:  J M Lehn; A V Eliseev
Journal:  Science       Date:  2001-03-23       Impact factor: 47.728

3.  Multicomponent Reactions with Isocyanides.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-09-15       Impact factor: 15.336

4.  Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly.

Authors:  I Huc; J M Lehn
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205
  4 in total
  7 in total

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2.  General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.

Authors:  Zhigang Xu; Muhammad Ayaz; Alexandra A Cappelli; Christopher Hulme
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Review 3.  Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds.

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Journal:  Mol Divers       Date:  2022-09-13       Impact factor: 3.364

5.  Synthesis of conformationally constrained tricyclic beta-lactam enantiomers through Ugi four-center three-component reactions of a monoterpene-based beta-amino acid.

Authors:  Zsolt Szakonyi; Reijo Sillanpää; Ferenc Fülöp
Journal:  Mol Divers       Date:  2009-04-15       Impact factor: 2.943

Review 6.  Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry.

Authors:  Christopher Hulme; Justin Dietrich
Journal:  Mol Divers       Date:  2009-02-11       Impact factor: 3.364

Review 7.  Multicomponent Reactions Accelerated by Aqueous Micelles.

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Journal:  Front Chem       Date:  2018-10-22       Impact factor: 5.221
  7 in total

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