Literature DB >> 11784164

An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction.

Y B Kim1, E H Choi, G Keum, S B Kang, D H Lee, H Y Koh, Y Kim.   

Abstract

A new one-pot procedure for the efficient synthesis of novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer as a bifunctional component with various alpha-amino acids and isocyanides by the Ugi five-center three-component reaction (U-5C-3CR) was developed. [reaction: see text]

Entities:  

Year:  2001        PMID： 11784164     DOI： 10.1021/ol016716w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

2.  One-pot multicomponent synthesis of two novel thiolactone scaffolds.

Authors:  B Beck; S Srivastava; K Khoury; E Herdtweck; Alexander Dömling
Journal:  Mol Divers       Date:  2010-04-21       Impact factor: 2.943

3.  Multicomponent synthesis of benzoxazinones via tandem Ugi/Mitsunobu reactions: an unexpected cine-substitution.

Authors:  Luca Banfi; Andrea Basso; Giuseppe Guanti; Paulina Lecinska; Renata Riva
Journal:  Mol Divers       Date:  2008-09-02       Impact factor: 2.943

4.  Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones.

Authors:  Steven Gunawan; Gary Nichol; Christopher Hulme
Journal:  Tetrahedron Lett       Date:  2012-01-28       Impact factor: 2.415

5.  Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

Authors:  Kareem Khoury; Mantosh K Sinha; Tadamichi Nagashima; Eberhardt Herdtweck; Alexander Dömling
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-11       Impact factor: 15.336

6.  An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction.

Authors:  Sangwon Cho; Gyochang Keum; Soon Bang Kang; So-Yeop Han; Youseung Kim
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

7.  Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles.

Authors:  Thimmalapura M Vishwanatha; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal:  J Org Chem       Date:  2017-08-25       Impact factor: 4.354

8.  Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds.

Authors:  Lisa Moni; Fabio De Moliner; Silvia Garbarino; Jörn Saupe; Christian Mang; Andrea Basso
Journal:  Front Chem       Date:  2018-09-06       Impact factor: 5.221
  8 in total

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