| Literature DB >> 16876404 |
Il Whea Ku1, Sangwon Cho, Munikumar Reddy Doddareddy, Min Seok Jang, Gyochang Keum, Jung-Ha Lee, Bong Young Chung, Youseung Kim, Hyewhon Rhim, Soon Bang Kang.
Abstract
Morpholin-2-one-5-carboxamide derivatives were prepared by using the one-pot Ugi multicomponent reaction and evaluated for blocking effects on T- and N-type Ca(2+) channels. Among them, compound 5i produced the highest potency (IC(50)=0.45+/-0.02 microM), while compounds 5d, 5f, 5k, 5n, 5o, and 6m produced relatively high potency as well as selectivity on T-type Ca(2+) channels. These novel scaffolds showed potent and selective T-type Ca(2+) channel blocking activities.Entities:
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Year: 2006 PMID： 16876404 DOI： 10.1016/j.bmcl.2006.05.031
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823