Literature DB >> 20332067

A high voltage asymmetric waveform generator for FAIMS.

Jesse D Canterbury1, James Gladden, Lon Buck, Roy Olund, Michael J MacCoss.   

Abstract

High field asymmetric waveform ion mobility spectrometry (FAIMS) has been used increasingly in recent years as an additional method of ion separation and selection before mass spectrometry. The FAIMS electrodes are relatively simple to design and fabricate for laboratories wishing to implement their own FAIMS designs. However, construction of the electronics apparatus needed to produce the required high magnitude asymmetric electric field oscillating at a frequency of several hundred kilohertz is not trivial. Here we present an entirely custom-built electronics setup capable of supplying the required waveforms and voltages. The apparatus is relatively simple and inexpensive to implement. We also present data acquired on this system demonstrating the use of FAIMS as a gas-phase ion filter interface to an ion trap mass spectrometer. Copyright 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20332067      PMCID: PMC2900502          DOI: 10.1016/j.jasms.2010.02.019

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN: 1044-0305            Impact factor:   3.109


  13 in total

1.  Analysis of a tryptic digest of pig hemoglobin using ESI-FAIMS-MS.

Authors:  R Guevremont; D A Barnett; R W Purves; J Vandermey
Journal:  Anal Chem       Date:  2000-10-01       Impact factor: 6.986

2.  Comparison of experimental and calculated peak shapes for three cylindrical geometry FAIMS prototypes of differing electrode diameters.

Authors:  Roger Guevremont; Randy Purves
Journal:  J Am Soc Mass Spectrom       Date:  2005-01-19       Impact factor: 3.109

3.  Compensation voltage (CV) peak shapes using a domed FAIMS with the inner electrode translated to various longitudinal positions.

Authors:  Roger Guevremont; Govindanunny Thekkadath; Christopher K Hilton
Journal:  J Am Soc Mass Spectrom       Date:  2005-04-15       Impact factor: 3.109

4.  Pressure effects in differential mobility spectrometry.

Authors:  Erkinjon G Nazarov; Stephen L Coy; Evgeny V Krylov; Raanan A Miller; Gary A Eiceman
Journal:  Anal Chem       Date:  2006-11-15       Impact factor: 6.986

5.  Feasibility of higher-order differential ion mobility separations using new asymmetric waveforms.

Authors:  Alexandre A Shvartsburg; Stefan V Mashkevich; Richard D Smith
Journal:  J Phys Chem A       Date:  2006-03-02       Impact factor: 2.781

6.  Characterization of a temperature-controlled FAIMS system.

Authors:  David A Barnett; Michael Belford; Jean-Jacques Dunyach; Randy W Purves
Journal:  J Am Soc Mass Spectrom       Date:  2007-06-22       Impact factor: 3.109

7.  Peak deconvolution in high-field asymmetric waveform ion mobility spectrometry (FAIMS) to characterize macromolecular conformations.

Authors:  Errol W Robinson; Rachel E Sellon; Evan R Williams
Journal:  Int J Mass Spectrom       Date:  2007-01-01       Impact factor: 1.986

8.  Optimum waveforms for differential ion mobility spectrometry (FAIMS).

Authors:  Alexandre A Shvartsburg; Richard D Smith
Journal:  J Am Soc Mass Spectrom       Date:  2008-05-16       Impact factor: 3.109

9.  Ultrafast differential ion mobility spectrometry at extreme electric fields in multichannel microchips.

Authors:  Alexandre A Shvartsburg; Richard D Smith; Ashley Wilks; Andrew Koehl; David Ruiz-Alonso; Billy Boyle
Journal:  Anal Chem       Date:  2009-08-01       Impact factor: 6.986

10.  Express analysis of explosives, chemical warfare agents and drugs with multicapillary column gas chromatography and ion mobility increment spectrometry.

Authors:  Igor A Buryakov
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2004-02-05       Impact factor: 3.205

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  3 in total

1.  Predicting compensation voltage for singly-charged ions in high-field asymmetric waveform ion mobility spectrometry (FAIMS).

Authors:  Alexander A Aksenov; James Kapron; Cristina E Davis
Journal:  J Am Soc Mass Spectrom       Date:  2012-08-08       Impact factor: 3.109

2.  Performance Enhancements in Differential Ion Mobility Spectrometry-Mass Spectrometry (DMS-MS) by Using a Modified CaptiveSpray Source.

Authors:  Ri Wu; Wei-Jing Wu; Ze Wang; Y-L Elaine Wong; Y-L Winnie Hung; H T Wong; Xiangfeng Chen; T-W Dominic Chan
Journal:  J Am Soc Mass Spectrom       Date:  2018-08-16       Impact factor: 3.109

3.  High-resolution differential ion mobility separations using planar analyzers at elevated dispersion fields.

Authors:  Alexandre A Shvartsburg; David C Prior; Keqi Tang; Richard D Smith
Journal:  Anal Chem       Date:  2010-09-15       Impact factor: 6.986

  3 in total

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