| Literature DB >> 20232928 |
Andrew Travers1, Edwige Hiriart, Mark Churcher, Micaela Caserta, Ernesto Di Mauro.
Abstract
The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.Entities:
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Year: 2010 PMID： 20232928 PMCID： PMC2864905 DOI： 10.1080/073911010010524942
Source DB: PubMed Journal: J Biomol Struct Dyn ISSN： 0739-1102