Literature DB >> 20201015

Critical functions of priming and lysosomal damage for NLRP3 activation.

Veit Hornung1, Eicke Latz.   

Abstract

Inflammasomes are cytosolic multi-protein complexes that form in response to infectious or injurious challenges. Inflammasomes control the activity of caspase-1, which is essential for the maturation and release of IL-1beta family cytokines. The NLRP1, IPAF and AIM2 inflammasomes recognize specific substances, while the NLRP3 inflammasome responds to many structurally and chemically diverse triggers. Here, we discuss the critical roles of priming and lysosomal damage in NLRP3 inflammasome activation.

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Year:  2010        PMID： 20201015      PMCID： PMC3893565          DOI： 10.1002/eji.200940185

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  22 in total

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4.  Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis.

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Journal:  J Immunol       Date:  2005-12-01       Impact factor: 5.422

Review 5.  Signaling by ROS drives inflammasome activation.

Authors:  Fabio Martinon
Journal:  Eur J Immunol       Date:  2010-03       Impact factor: 5.532

6.  Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.

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Journal:  Immunity       Date:  2007-04-12       Impact factor: 31.745

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Journal:  Nature       Date:  2006-01-11       Impact factor: 49.962

8.  Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.

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  120 in total

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Review 2.  Inflammasomes in health and disease.

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Journal:  Nature       Date:  2012-01-18       Impact factor: 49.962

3.  Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.

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Journal:  Nat Commun       Date:  2012-03-27       Impact factor: 14.919

Review 4.  Molecular mechanisms regulating NLRP3 inflammasome activation.

Authors:  Eun-Kyeong Jo; Jin Kyung Kim; Dong-Min Shin; Chihiro Sasakawa
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Authors:  Wei Li; Barry P Katz; Margaret E Bauer; Stanley M Spinola
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7.  Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.

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8.  Curcumin: a double hit on malignant mesothelioma.

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9.  NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.

Authors:  Wen Allen Tseng; Thuzar Thein; Kati Kinnunen; Kameran Lashkari; Meredith S Gregory; Patricia A D'Amore; Bruce R Ksander
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-07       Impact factor: 4.799

Review 10.  Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.

Authors:  Matthew G Frank; Linda R Watkins; Steven F Maier
Journal:  Brain Behav Immun       Date:  2013-03-01       Impact factor: 7.217
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