Literature DB >> 20971108

Activation of the NLRP3 inflammasome by intracellular poly I:C.

Jayant V Rajan1, Sarah E Warren, Edward A Miao, Alan Aderem.   

Abstract

Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20971108      PMCID： PMC3005299          DOI： 10.1016/j.febslet.2010.10.036

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

1.  Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses.

Authors:  Friedemann Weber; Valentina Wagner; Simon B Rasmussen; Rune Hartmann; Søren R Paludan
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

2.  The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response.

Authors:  Daniel A Muruve; Virginie Pétrilli; Anne K Zaiss; Lindsay R White; Sharon A Clark; P Joel Ross; Robin J Parks; Jurg Tschopp
Journal:  Nature       Date:  2008-02-20       Impact factor: 49.962

Review 3.  The inflammasomes: guardians of the body.

Authors:  Fabio Martinon; Annick Mayor; Jürg Tschopp
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527

4.  An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

Authors:  Tilmann Bürckstümmer; Christoph Baumann; Stephan Blüml; Evelyn Dixit; Gerhard Dürnberger; Hannah Jahn; Melanie Planyavsky; Martin Bilban; Jacques Colinge; Keiryn L Bennett; Giulio Superti-Furga
Journal:  Nat Immunol       Date:  2009-01-21       Impact factor: 25.606

5.  Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.

Authors:  Thirumala-Devi Kanneganti; Mathilde Body-Malapel; Amal Amer; Jong-Hwan Park; Joel Whitfield; Luigi Franchi; Zenobia F Taraporewala; David Miller; John T Patton; Naohiro Inohara; Gabriel Núñez
Journal:  J Biol Chem       Date:  2006-09-28       Impact factor: 5.157

6.  Cytosolic antiviral RNA recognition pathway activates caspases 1 and 3.

Authors:  Johanna Rintahaka; Daniel Wiik; Panu E Kovanen; Harri Alenius; Sampsa Matikainen
Journal:  J Immunol       Date:  2008-02-01       Impact factor: 5.422

7.  HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.

Authors:  Tara L Roberts; Adi Idris; Jasmyn A Dunn; Greg M Kelly; Carol M Burnton; Samantha Hodgson; Lani L Hardy; Valerie Garceau; Matthew J Sweet; Ian L Ross; David A Hume; Katryn J Stacey
Journal:  Science       Date:  2009-01-08       Impact factor: 47.728

8.  Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.

Authors:  Veit Hornung; Franz Bauernfeind; Annett Halle; Eivind O Samstad; Hajime Kono; Kenneth L Rock; Katherine A Fitzgerald; Eicke Latz
Journal:  Nat Immunol       Date:  2008-07-11       Impact factor: 25.606

9.  Inflammasome recognition of influenza virus is essential for adaptive immune responses.

Authors:  Takeshi Ichinohe; Heung Kyu Lee; Yasunori Ogura; Richard Flavell; Akiko Iwasaki
Journal:  J Exp Med       Date:  2009-01-12       Impact factor: 14.307

10.  AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.

Authors:  Veit Hornung; Andrea Ablasser; Marie Charrel-Dennis; Franz Bauernfeind; Gabor Horvath; Daniel R Caffrey; Eicke Latz; Katherine A Fitzgerald
Journal:  Nature       Date:  2009-01-21       Impact factor: 49.962
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  26 in total

1.  Toll-like receptor expression and induction of type I and type III interferons in primary airway epithelial cells.

Authors:  Ioannis Ioannidis; Fang Ye; Beth McNally; Meredith Willette; Emilio Flaño
Journal:  J Virol       Date:  2013-01-09       Impact factor: 5.103

Review 2.  Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.

Authors:  Surya Pandey; Taro Kawai; Shizuo Akira
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-10-09       Impact factor: 10.005

3.  Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunction.

Authors:  Elsie Gonzalez-Hurtado; Jieun Lee; Joseph Choi; Ebru S Selen Alpergin; Samuel L Collins; Maureen R Horton; Michael J Wolfgang
Journal:  Am J Physiol Endocrinol Metab       Date:  2017-02-21       Impact factor: 4.310

4.  Human NLRP3 inflammasome senses multiple types of bacterial RNAs.

Authors:  Wenwen Sha; Hiroki Mitoma; Shino Hanabuchi; Musheng Bao; Leiyun Weng; Naoshi Sugimoto; Ying Liu; Zhiqiang Zhang; Jin Zhong; Bing Sun; Yong-Jun Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-29       Impact factor: 11.205

5.  Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A.

Authors:  Chelsea A Embry; Luigi Franchi; Gabriel Nuñez; Thomas C Mitchell
Journal:  Sci Signal       Date:  2011-05-03       Impact factor: 8.192

6.  The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.

Authors:  Naeha Subramanian; Kannan Natarajan; Menna R Clatworthy; Ze Wang; Ronald N Germain
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

7.  25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.

Authors:  Elizabeth S Gold; Alan H Diercks; Irina Podolsky; Rebecca L Podyminogin; Peter S Askovich; Piper M Treuting; Alan Aderem
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-03       Impact factor: 11.205

8.  The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.

Authors:  Leiyun Weng; Hiroki Mitoma; Coline Trichot; Coline Tricot; Musheng Bao; Ying Liu; Zhiqiang Zhang; Yong-Jun Liu
Journal:  J Immunol       Date:  2014-08-29       Impact factor: 5.422

9.  The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome.

Authors:  Hiroki Mitoma; Shino Hanabuchi; Taeil Kim; Musheng Bao; Zhiqiang Zhang; Naoshi Sugimoto; Yong-Jun Liu
Journal:  Immunity       Date:  2013-07-18       Impact factor: 31.745

Review 10.  The expanding role of NLRs in antiviral immunity.

Authors:  Christopher Lupfer; Thirumala-Devi Kanneganti
Journal:  Immunol Rev       Date:  2013-09       Impact factor: 12.988
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