Literature DB >> 20201014

Signaling by ROS drives inflammasome activation.

Fabio Martinon1.   

Abstract

Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.

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Year:  2010        PMID： 20201014     DOI： 10.1002/eji.200940168

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  219 in total

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Review 2.  Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease.

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Journal:  Nat Rev Immunol       Date:  2016-01       Impact factor: 53.106

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Authors:  Bruna M Schweinberger; André F Rodrigues; Elias Turcatel; Paula Pierozan; Leticia F Pettenuzzo; Mateus Grings; Giselli Scaini; Mariana M Parisi; Guilhian Leipnitz; Emilio L Streck; Florencia M Barbé-Tuana; Angela T S Wyse
Journal:  Mol Neurobiol       Date:  2017-01-13       Impact factor: 5.590

4.  Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction.

Authors:  Lisa M Weatherly; Hillary L Shane; Sherri A Friend; Ewa Lukomska; Rachel Baur; Stacey E Anderson
Journal:  Toxicol Sci       Date:  2020-07-01       Impact factor: 4.849

5.  NLRP3-inflammasomes are triggered by age-related hearing loss in the inner ear of mice.

Authors:  Xi Shi; Shiwei Qiu; Wei Zhuang; Na Yuan; Caiji Wang; Shili Zhang; Tiantian Sun; Weiwei Guo; Fenglei Gao; Shiming Yang; Yuehua Qiao
Journal:  Am J Transl Res       Date:  2017-12-15       Impact factor: 4.060

Review 6.  Emerging role of antioxidants in the protection of uveitis complications.

Authors:  U C S Yadav; N M Kalariya; K V Ramana
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

7.  Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.

Authors:  Shankar S Iyer; Qiong He; John R Janczy; Suzanne L Cassel; Fayyaz S Sutterwala; Eric I Elliott; Zhenyu Zhong; Alicia K Olivier; Jeffrey J Sadler; Vickie Knepper-Adrian; Renzhi Han; Liang Qiao; Stephanie C Eisenbarth; William M Nauseef
Journal:  Immunity       Date:  2013-08-15       Impact factor: 31.745

8.  Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Authors:  Gabriel S Chiu; Diptaman Chatterjee; Patrick T Darmody; John P Walsh; Daryl D Meling; Rodney W Johnson; Gregory G Freund
Journal:  J Neurosci       Date:  2012-10-03       Impact factor: 6.167

Review 9.  NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

Authors:  Evan A Bordt; Brian M Polster
Journal:  Free Radic Biol Med       Date:  2014-08-01       Impact factor: 7.376

10.  Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.

Authors:  Leah R Villegas; Dylan Kluck; Carlie Field; Rebecca E Oberley-Deegan; Crystal Woods; Michael E Yeager; Karim C El Kasmi; Rashmin C Savani; Russell P Bowler; Eva Nozik-Grayck
Journal:  Antioxid Redox Signal       Date:  2013-02-05       Impact factor: 8.401
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