Literature DB >> 20162084

The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).

Jean Bickii1, Guy Raymond Feuya Tchouya, Jean Claude Tchouankeu, Etienne Tsamo.   

Abstract

In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.

Entities:  

Keywords:  24-methylenecycloartenol; 7α-obacunyl acetate; Entandrophragma angolense; Fatty acids; Limonoids; Meliaceae; Plasmodium falciparum; Triterpenoids; anti-plasmodial activity

Year:  2006        PMID： 20162084      PMCID： PMC2816453     

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  12 in total

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5.  In vitro antimalarial activity of Coutarea latiflora and Exostema caribaeum extracts on Plasmodium falciparum.

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7.  Antimalarial activity of Tanzanian plants and their active constituents: the genus Uvaria.

Authors:  M H Nkunya; H Weenen; D H Bray; Q A Mgani; L B Mwasumbi
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8.  Synchronization of Plasmodium falciparum erythrocytic stages in culture.

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Journal:  Planta Med       Date:  1992-12       Impact factor: 3.352

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Authors:  P O Obih; M Makinde; O J Laoye
Journal:  Afr J Med Med Sci       Date:  1985 Mar-Jun
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  8 in total

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