| Literature DB >> 33588006 |
Isoo Youn1, Zhenlong Wu2, Samiya Papa1, Joanna E Burdette1, Bamisaye O Oyawaluja3, Hyun Lee1, Chun-Tao Che4.
Abstract
Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC50 values ranging from 2.0-5.9 μM.Entities:
Keywords: Cytotoxicity; Entandrophragma angolense; Limonoid; Meliaceae; Quantitative NMR; Triterpenoid; seco-triterpenoid
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Year: 2021 PMID: 33588006 PMCID: PMC8318517 DOI: 10.1016/j.fitote.2021.104846
Source DB: PubMed Journal: Fitoterapia ISSN: 0367-326X Impact factor: 2.882