Literature DB >> 19536100

Open access chemical and clinical probes to support drug discovery.

Aled M Edwards1, Chas Bountra, David J Kerr, Timothy M Willson.   

Abstract

Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships. Chemical biologists could play a central role in this effort.

Mesh：

Substances：

Year:  2009        PMID： 19536100     DOI： 10.1038/nchembio0709-436

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  22 in total

Review 1.  Orphan nuclear receptors: shifting endocrinology into reverse.

Authors:  S A Kliewer; J M Lehmann; T M Willson
Journal:  Science       Date:  1999-04-30       Impact factor: 47.728

2.  Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.

Authors:  P W Mantyh; S D Rogers; P Honore; B J Allen; J R Ghilardi; J Li; R S Daughters; D A Lappi; R G Wiley; D A Simone
Journal:  Science       Date:  1997-10-10       Impact factor: 47.728

3.  An index to quantify an individual's scientific research output.

Authors:  J E Hirsch
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-07       Impact factor: 11.205

4.  Chemical genetics: where genetics and pharmacology meet.

Authors:  Zachary A Knight; Kevan M Shokat
Journal:  Cell       Date:  2007-02-09       Impact factor: 41.582

Review 5.  MMPs as therapeutic targets--still a viable option?

Authors:  Barbara Fingleton
Journal:  Semin Cell Dev Biol       Date:  2007-07-06       Impact factor: 7.727

6.  Rebuilding the R&D engine in big pharma.

Authors:  Jean-Pierre Garnier
Journal:  Harv Bus Rev       Date:  2008-05

7.  Pain, tenderness, wheal and flare induced by substance-P, bradykinin and 5-hydroxytryptamine in humans.

Authors:  K Jensen; C Tuxen; U Pedersen-Bjergaard; I Jansen
Journal:  Cephalalgia       Date:  1991-09       Impact factor: 6.292

Review 8.  Nuclear receptors and lipid physiology: opening the X-files.

Authors:  A Chawla; J J Repa; R M Evans; D J Mangelsdorf
Journal:  Science       Date:  2001-11-30       Impact factor: 47.728

9.  Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis.

Authors:  C J Menkes; M Renoux; S Laoussadi; A Mauborgne; J Bruxelle; F Cesselin
Journal:  J Rheumatol       Date:  1993-04       Impact factor: 4.666

10.  Algesia and local responses induced by neurokinin A and substance P in human skin and temporal muscle.

Authors:  U Pedersen-Bjergaard; L B Nielsen; K Jensen; L Edvinsson; I Jansen; J Olesen
Journal:  Peptides       Date:  1989 Nov-Dec       Impact factor: 3.750
View more
  46 in total

1.  Identifying mechanism-of-action targets for drugs and probes.

Authors:  Elisabet Gregori-Puigjané; Vincent Setola; Jérôme Hert; Brenda A Crews; John J Irwin; Eugen Lounkine; Lawrence Marnett; Bryan L Roth; Brian K Shoichet
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

2.  New approaches to rewarding pharmaceutical innovation.

Authors:  Paul Grootendorst; Aidan Hollis; David K Levine; Thomas Pogge; Aled M Edwards
Journal:  CMAJ       Date:  2010-12-13       Impact factor: 8.262

3.  Comprehensive characterization of the Published Kinase Inhibitor Set.

Authors:  Jonathan M Elkins; Vita Fedele; Marta Szklarz; Kamal R Abdul Azeez; Eidarus Salah; Jowita Mikolajczyk; Sergei Romanov; Nikolai Sepetov; Xi-Ping Huang; Bryan L Roth; Ayman Al Haj Zen; Denis Fourches; Eugene Muratov; Alex Tropsha; Joel Morris; Beverly A Teicher; Mark Kunkel; Eric Polley; Karen E Lackey; Francis L Atkinson; John P Overington; Paul Bamborough; Susanne Müller; Daniel J Price; Timothy M Willson; David H Drewry; Stefan Knapp; William J Zuercher
Journal:  Nat Biotechnol       Date:  2015-10-26       Impact factor: 54.908

4.  21(st) Century Cures Act: An Act of Cure or Diagnosis?

Authors:  David A Brindley; Zeeshaan Arshad; Dee Luo; Sue Dopson; Georg Hollander; Stephen Frost; Chas Bountra; James A Smith
Journal:  Rejuvenation Res       Date:  2015-08       Impact factor: 4.663

5.  US academic drug discovery.

Authors:  Stephen Frye; Marina Crosby; Teresa Edwards; Rudolph Juliano
Journal:  Nat Rev Drug Discov       Date:  2011-06       Impact factor: 84.694

6.  The art of the chemical probe.

Authors:  Stephen V Frye
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

7.  Are patents impeding medical care and innovation?

Authors:  E Richard Gold; Warren Kaplan; James Orbinski; Sarah Harland-Logan; Sevil N-Marandi
Journal:  PLoS Med       Date:  2010-01-05       Impact factor: 11.069

Review 8.  The role of medical structural genomics in discovering new drugs for infectious diseases.

Authors:  Wesley C Van Voorhis; Wim G J Hol; Peter J Myler; Lance J Stewart
Journal:  PLoS Comput Biol       Date:  2009-10-26       Impact factor: 4.475

9.  SGC--structural biology and human health: a new approach to publishing structural biology results.

Authors:  Wen Hwa Lee; Julián Atienza-Herrero; Ruben Abagyan; Brian D Marsden
Journal:  PLoS One       Date:  2009-10-20       Impact factor: 3.240

10.  Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Authors:  Nathan R Rose; Esther C Y Woon; Guy L Kingham; Oliver N F King; Jasmin Mecinović; Ian J Clifton; Stanley S Ng; Jobina Talib-Hardy; Udo Oppermann; Michael A McDonough; Christopher J Schofield
Journal:  J Med Chem       Date:  2010-02-25       Impact factor: 7.446
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.