Literature DB >> 19465930

Inhibitors paradoxically prime kinases.

Stephen V Frye, Gary L Johnson.   

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Year:  2009        PMID： 19465930     DOI： 10.1038/nchembio.f.11

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  12 in total

Review 1.  Functional selectivity and classical concepts of quantitative pharmacology.

Authors:  Jonathan D Urban; William P Clarke; Mark von Zastrow; David E Nichols; Brian Kobilka; Harel Weinstein; Jonathan A Javitch; Bryan L Roth; Arthur Christopoulos; Patrick M Sexton; Keith J Miller; Michael Spedding; Richard B Mailman
Journal:  J Pharmacol Exp Ther       Date:  2006-06-27       Impact factor: 4.030

2.  A quantitative analysis of kinase inhibitor selectivity.

Authors:  Mazen W Karaman; Sanna Herrgard; Daniel K Treiber; Paul Gallant; Corey E Atteridge; Brian T Campbell; Katrina W Chan; Pietro Ciceri; Mindy I Davis; Philip T Edeen; Raffaella Faraoni; Mark Floyd; Jeremy P Hunt; Daniel J Lockhart; Zdravko V Milanov; Michael J Morrison; Gabriel Pallares; Hitesh K Patel; Stephanie Pritchard; Lisa M Wodicka; Patrick P Zarrinkar
Journal:  Nat Biotechnol       Date:  2008-01       Impact factor: 54.908

3.  Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.

Authors:  Yan Luo; Alexander R Shoemaker; Xuesong Liu; Keith W Woods; Sheela A Thomas; Ron de Jong; Edward K Han; Tongmei Li; Vincent S Stoll; Jessica A Powlas; Anatol Oleksijew; Michael J Mitten; Yan Shi; Ran Guan; Thomas P McGonigal; Vered Klinghofer; Eric F Johnson; Joel D Leverson; Jennifer J Bouska; Mulugeta Mamo; Richard A Smith; Emily E Gramling-Evans; Bradley A Zinker; Amanda K Mika; Phong T Nguyen; Tilman Oltersdorf; Saul H Rosenberg; Qun Li; Vincent L Giranda
Journal:  Mol Cancer Ther       Date:  2005-06       Impact factor: 6.261

4.  Rational design of inhibitors that bind to inactive kinase conformations.

Authors:  Yi Liu; Nathanael S Gray
Journal:  Nat Chem Biol       Date:  2006-07       Impact factor: 15.040

5.  The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation.

Authors:  A Behn-Krappa; A C Newton
Journal:  Curr Biol       Date:  1999-07-15       Impact factor: 10.834

6.  A chemical switch for inhibitor-sensitive alleles of any protein kinase.

Authors:  A C Bishop; J A Ubersax; D T Petsch; D P Matheos; N S Gray; J Blethrow; E Shimizu; J Z Tsien; P G Schultz; M D Rose; J L Wood; D O Morgan; K M Shokat
Journal:  Nature       Date:  2000-09-21       Impact factor: 49.962

7.  Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.

Authors:  E K-H Han; J D Leverson; T McGonigal; O J Shah; K W Woods; T Hunter; V L Giranda; Y Luo
Journal:  Oncogene       Date:  2007-03-05       Impact factor: 9.867

8.  A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.

Authors:  Edgar R Wood; Anne T Truesdale; Octerloney B McDonald; Derek Yuan; Anne Hassell; Scott H Dickerson; Byron Ellis; Christopher Pennisi; Earnest Horne; Karen Lackey; Krystal J Alligood; David W Rusnak; Tona M Gilmer; Lisa Shewchuk
Journal:  Cancer Res       Date:  2004-09-15       Impact factor: 12.701

9.  PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

Authors:  Angus J M Cameron; Cristina Escribano; Adrian T Saurin; Brenda Kostelecky; Peter J Parker
Journal:  Nat Struct Mol Biol       Date:  2009-05-24       Impact factor: 15.369

10.  Inhibitor hijacking of Akt activation.

Authors:  Tatsuya Okuzumi; Dorothea Fiedler; Chao Zhang; Daniel C Gray; Brian Aizenstein; Randy Hoffman; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2009-05-24       Impact factor: 15.040
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  7 in total

1.  A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism.

Authors:  Patrick Corsino; Nicole Horenstein; David Ostrov; Thomas Rowe; Mary Law; Amanda Barrett; George Aslanidi; W Douglas Cress; Brian Law
Journal:  J Biol Chem       Date:  2009-08-26       Impact factor: 5.157

2.  The art of the chemical probe.

Authors:  Stephen V Frye
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

3.  Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

Authors:  Sonja J Heidorn; Carla Milagre; Steven Whittaker; Arnaud Nourry; Ion Niculescu-Duvas; Nathalie Dhomen; Jahan Hussain; Jorge S Reis-Filho; Caroline J Springer; Catrin Pritchard; Richard Marais
Journal:  Cell       Date:  2010-01-22       Impact factor: 41.582

4.  Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.

Authors:  Jason M Fritz; Lori D Dwyer-Nield; Alvin M Malkinson
Journal:  Mol Cancer       Date:  2011-06-24       Impact factor: 27.401

5.  GCN2 kinase activation by ATP-competitive kinase inhibitors.

Authors:  Colin P Tang; Owen Clark; John R Ferrarone; Carl Campos; Alshad S Lalani; John D Chodera; Andrew M Intlekofer; Olivier Elemento; Ingo K Mellinghoff
Journal:  Nat Chem Biol       Date:  2021-12-23       Impact factor: 16.174

6.  Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor.

Authors:  Elisabeth Bou-Petit; Stefan Hümmer; Helena Alarcon; Konstantin Slobodnyuk; Marta Cano-Galietero; Pedro Fuentes; Pedro J Guijarro; María José Muñoz; Leticia Suarez-Cabrera; Anna Santamaria; Roger Estrada-Tejedor; José I Borrell; Santiago Ramón Y Cajal
Journal:  J Med Chem       Date:  2022-04-13       Impact factor: 8.039

Review 7.  The dynamic nature of the kinome.

Authors:  Lee M Graves; James S Duncan; Martin C Whittle; Gary L Johnson
Journal:  Biochem J       Date:  2013-02-15       Impact factor: 3.857
  7 in total

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